PMID- 21697743
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20211203
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 53
IP  - 6
DP  - 2011 Dec
TI  - Early developing celiac disease in children with cerebral palsy.
PG  - 674-8
LID - 10.1097/MPG.0b013e318229889d [doi]
AB  - OBJECTIVES: We have reported on increased levels of antibodies against gliadin 
      and/or transglutaminase 2 (TG2) in children with cerebral palsy (CP) but without 
      having increased prevalence of celiac disease (CD). The aim of the present study 
      was to evaluate whether these children have mucosal signs of early developing CD, 
      human leukocyte antigen (HLA)-DQ2/DQ8, and antibodies against deamidated gliadin 
      peptides (DGP). PATIENTS AND METHODS: Stored blood samples from 16 children with 
      CP were analyzed regarding HLA-DQ2/DQ8 and anti-DGP antibodies. HLA-DQ2/DQ8 were 
      analyzed by polymerase chain reaction sequence-specific oligonucleotide probes. 
      Anti-DGP antibodies were analyzed with enzyme-linked immunosorbent assay. 
      Small-bowel biopsies from 15 of these children were available for 
      immunohistochemistry regarding IgA colocalized with TG2, densities of alpha/beta+ and 
      gamma/delta+ intraepithelial lymphocytes. RESULTS: Mucosal immunoglobulin A (IgA) 
      deposits colocalized with TG2 were found in the small-bowel biopsy from 1 patient 
      with serum IgA-class anti-TG2 antibodies, HLA-DQ2, and gastrointestinal 
      complaints. Another 2 children had slightly increased numbers of mucosal alpha/beta+ 
      and/or gamma/delta+ intraepithelial lymphocytes. In total, 10 of 16 children were HLA-DQ2 
      and/or DQ8-positive. Anti-DGP antibodies were detected in sera from 4 of 16 
      children. CONCLUSIONS: In the present study, 1 child with CP had IgA colocalizing 
      with TG2 in the small-bowel mucosa, suggesting CD at an early stage. Although the 
      majority of children with CP and elevated levels of CD-related seromarkers are 
      HLA-DQ2 and/or DQ8-positive, they have neither classical nor early developing CD.
FAU - Stenberg, Reidun
AU  - Stenberg R
AD  - Department of Paediatrics, Orebro University Hospital, Orebro, Sweden. 
      reidun.stenberg@orebroll.se
FAU - Kaukinen, Katri
AU  - Kaukinen K
FAU - Bengtsson, Mats
AU  - Bengtsson M
FAU - Lindberg, Eva
AU  - Lindberg E
FAU - Dahle, Charlotte
AU  - Dahle C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (Antibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (Immunoglobulin A)
RN  - 9007-90-3 (Gliadin)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adolescent
MH  - Antibodies/blood
MH  - Biomarkers/blood
MH  - Biopsy/methods
MH  - Celiac Disease/*complications/*diagnosis/pathology
MH  - Cerebral Palsy/*complications/pathology
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - GTP-Binding Proteins/immunology
MH  - Gliadin/immunology
MH  - HLA-DQ Antigens/blood
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Intestinal Mucosa/*pathology
MH  - Intestine, Small/*pathology
MH  - Male
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - Transglutaminases/immunology
EDAT- 2011/06/24 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - 10.1097/MPG.0b013e318229889d [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2011 Dec;53(6):674-8. doi: 
      10.1097/MPG.0b013e318229889d.