PMID- 21698087
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20211020
IS  - 1612-3174 (Electronic)
IS  - 1612-3174 (Linking)
VI  - 9
DP  - 2011
TI  - Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical 
      features and outcome of a retrospective analysis.
PG  - Doc11
LID - 10.3205/000134 [doi]
LID - Doc11
AB  - We analyzed clinical outcome of patients with an isolated central nervous system 
      lymphoma (CNSL) relapse after systemic non-Hodgkin's lymphoma (NHL). All 23 
      patients with an isolated secondary CNSL (SCNSL) treated at two institutions from 
      04/2003-12/2007 were included into this analysis. At cerebral relapse, 15/23 
      patients were treated with a regimen consisting of high-dose methotrexate (Bonn 
      protocol). After a median follow-up of 6.5 months (range 1-68), 15/23 (65%) 
      patients with SCNSL had relapsed or progressed. HD (high-dose)- methotrexate 
      (MTX) chemotherapy according to the Bonn protocol is effective concerning 
      response rates; however, overall survival of patients with SCNSL seems to be 
      impaired in comparison to relapses in primary CNSL (PCNSL).
FAU - Patrij, Katrin
AU  - Patrij K
AD  - Center for Integrated Oncology, University of Bonn, Bonn, Germany.
FAU - Reiser, Marcel
AU  - Reiser M
FAU - Watzel, Luise
AU  - Watzel L
FAU - Pels, Hendrik
AU  - Pels H
FAU - Kowoll, Annika
AU  - Kowoll A
FAU - Herrlinger, Ulrich
AU  - Herrlinger U
FAU - Engert, Andreas
AU  - Engert A
FAU - Linnebank, Michael
AU  - Linnebank M
FAU - Schackert, Gabriele
AU  - Schackert G
FAU - Vogt-Schaden, Marlies
AU  - Vogt-Schaden M
FAU - Egerer, Gerlinde
AU  - Egerer G
FAU - Lamprecht, Monika
AU  - Lamprecht M
FAU - Batchelor, Tracy T
AU  - Batchelor TT
FAU - Schlegel, Uwe
AU  - Schlegel U
FAU - Schmidt-Wolf, Ingo G H
AU  - Schmidt-Wolf IG
CN  - International Primary CNS Lymphoma Collaborative Group (IPCG)
LA  - eng
GR  - R13 CA124293/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20110502
PL  - Germany
TA  - Ger Med Sci
JT  - German medical science : GMS e-journal
JID - 101227686
RN  - 04079A1RDZ (Cytarabine)
RN  - 5J49Q6B70F (Vincristine)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - RSA8KO39WH (Vindesine)
RN  - UM20QQM95Y (Ifosfamide)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Central Nervous System Neoplasms/*drug therapy/radiotherapy
MH  - Cyclophosphamide/administration & dosage
MH  - Cytarabine/administration & dosage
MH  - Dexamethasone/administration & dosage
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Ifosfamide/administration & dosage
MH  - Kaplan-Meier Estimate
MH  - Lymphoma, Follicular/*drug therapy/radiotherapy
MH  - Lymphoma, Large B-Cell, Diffuse/*drug therapy/radiotherapy
MH  - Male
MH  - Methotrexate/administration & dosage
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*drug therapy/radiotherapy
MH  - Retrospective Studies
MH  - *Salvage Therapy
MH  - Treatment Outcome
MH  - Vincristine/administration & dosage
MH  - Vindesine/administration & dosage
PMC - PMC3118693
OTO - NOTNLM
OT  - CNS
OT  - chemotherapy
OT  - lymphoma
OT  - methotrexate
OT  - neoplasia
OT  - relapse
EDAT- 2011/06/24 06:00
MHDA- 2011/12/13 00:00
PMCR- 2011/05/02
CRDT- 2011/06/24 06:00
PHST- 2010/12/27 00:00 [received]
PHST- 2011/04/19 00:00 [revised]
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2011/05/02 00:00 [pmc-release]
AID - 000134 [pii]
AID - 10.3205/000134 [doi]
PST - ppublish
SO  - Ger Med Sci. 2011;9:Doc11. doi: 10.3205/000134. Epub 2011 May 2.