PMID- 21698705
OWN - NLM
STAT- MEDLINE
DCOM- 20111104
LR  - 20110623
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Jul
TI  - Investigation of acupoint specificity by multivariate granger causality analysis 
      from functional MRI data.
PG  - 31-42
LID - 10.1002/jmri.22585 [doi]
AB  - PURPOSE: To investigate the acupoint specificity by exploring the effective 
      connectivity patterns of the poststimulus resting brain networks modulated by 
      acupuncture at the PC6, with the same meridian acupoint PC7 and different 
      meridian acupoint GB37. MATERIALS AND METHODS: The functional MRI (fMRI) study 
      was performed in 36 healthy right-handed subjects receiving acupuncture at three 
      acupoints, respectively. Due to the sustained effects of acupuncture, a novel 
      experimental paradigm using the nonrepeated event-related (NRER) design was 
      adopted. Psychophysical responses (deqi sensations) were also assessed. Finally, 
      a newly multivariate Granger causality analysis (mGCA) was used to analyze 
      effective connectivity patterns of the resting fMRI data taken following 
      acupuncture at three acupoints. RESULTS: Following acupuncture at PC6, the red 
      nucleus and substantia nigra emerged as central hubs, in comparison with the 
      fusiform gyrus following acupuncture at GB37. Red nucleus was also a target 
      following acupuncture at PC7, but with fewer inputs than those of PC6. In 
      addition, the most important target following acupuncture at PC7 was located at 
      the parahippocampus. CONCLUSION: Our findings demonstrated that acupuncture at 
      different acupoints may exert heterogeneous modulatory effects on the causal 
      interactions of brain areas during the poststimulus resting state. These 
      preliminary findings provided a clue to elucidate the relatively 
      function-oriented specificity of acupuncture effects.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Feng, Yuanyuan
AU  - Feng Y
AD  - Key Laboratory of Complex Systems and Intelligence Science, Institute of 
      Automation, Chinese Academy of Sciences, Beijing, China.
FAU - Bai, Lijun
AU  - Bai L
FAU - Zhang, Wensheng
AU  - Zhang W
FAU - Xue, Ting
AU  - Xue T
FAU - Ren, Yanshuang
AU  - Ren Y
FAU - Zhong, Chongguang
AU  - Zhong C
FAU - Wang, Hu
AU  - Wang H
FAU - You, Youbo
AU  - You Y
FAU - Liu, Zhenyu
AU  - Liu Z
FAU - Dai, Jianping
AU  - Dai J
FAU - Liu, Yijun
AU  - Liu Y
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - *Acupuncture Points
MH  - Acupuncture Therapy/*methods
MH  - Adult
MH  - Brain/*pathology
MH  - Brain Mapping/*methods
MH  - Female
MH  - Hippocampus/physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Models, Statistical
MH  - Multivariate Analysis
MH  - Red Nucleus/physiology
MH  - Reproducibility of Results
EDAT- 2011/06/24 06:00
MHDA- 2011/11/05 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/11/05 06:00 [medline]
AID - 10.1002/jmri.22585 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2011 Jul;34(1):31-42. doi: 10.1002/jmri.22585.