PMID- 21699450
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20131121
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 33
IP  - 4
DP  - 2011
TI  - Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect 
      in the rostral ventrolateral medulla of obesity-induced hypertensive rats.
PG  - 240-5
LID - 10.3109/10641963.2011.583969 [doi]
AB  - In the patients and animals with metabolic syndrome (MetS), sympathetic nerve 
      activity (SNA) is increased. We have demonstrated that oxidative stress in the 
      rostral ventrolateral medulla (RVLM), a vasomotor center in the brainstem, 
      increases SNA. The aim of the present study was to determine whether calorie 
      restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced 
      obesity rats. Male Sprague-Dawley rats were fed on a high-fat diet and segregated 
      into obesity-prone (OP) showing a MetS profile and obesity-resistant (OR) after 
      13 weeks. Obesity-prone was divided into OP treated with calorie restriction 
      (CR-OP) for 8 weeks and control (CTR-OP). Systolic blood pressure (SBP), heart 
      rate (HR), SNA, and thiobarbituric acid-reactive substances (TBARS) levels as a 
      marker of oxidative stress in the RVLM were significantly higher and the 
      depressor effects due to the microinjection of tempol, a superoxide dismutase 
      mimetic into the RVLM, were significantly greater in OP than in OR. Body weight 
      was significantly lower in CR-OP than in CTR-OP. SBP, HR, SNA, TBARS, and the 
      depressor effects due to the microinjection of tempol into the RVLM were 
      significantly lower in CR-OP than in CTR-OP. These results suggest that calorie 
      restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced 
      obesity rats.
FAU - Kishi, Takuya
AU  - Kishi T
AD  - Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu 
      University Graduate School of Medical Sciences, Fukuoka, Japan. 
      tkishi@cardiol.med.kyushu-u.ac.jp
FAU - Hirooka, Yoshitaka
AU  - Hirooka Y
FAU - Ogawa, Kiyohiro
AU  - Ogawa K
FAU - Konno, Satomi
AU  - Konno S
FAU - Sunagawa, Kenji
AU  - Sunagawa K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0 (Antioxidants)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Blood Pressure/physiology
MH  - Body Weight/physiology
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Heart Rate/physiology
MH  - Hypertension/*etiology/*physiopathology
MH  - Male
MH  - Medulla Oblongata/*metabolism/physiopathology
MH  - Norepinephrine/urine
MH  - Obesity/*complications/metabolism
MH  - Oxidative Stress/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sympathetic Nervous System/*physiopathology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2011/06/28 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.3109/10641963.2011.583969 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2011;33(4):240-5. doi: 10.3109/10641963.2011.583969.