PMID- 21699788
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20220316
IS  - 1528-0012 (Electronic)
IS  - 0016-5085 (Linking)
VI  - 141
IP  - 3
DP  - 2011 Sep
TI  - HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but 
      reduces risk for Crohn's disease.
PG  - 864-871.e1-5
LID - 10.1053/j.gastro.2011.05.048 [doi]
AB  - BACKGROUND & AIMS: There are many genetic factors that are associated with both 
      ulcerative colitis (UC) and Crohn's disease (CD). However, genetic factors that 
      have distinct effects on UC and CD have not been examined. METHODS: We performed 
      a comparative genome-wide association study (GWAS) and a replication study using 
      data from 748 patients with UC and 979 with CD, selected from a Japanese 
      population. We conducted high-resolution (4-digit) genotyping of human leukocyte 
      antigen (HLA) alleles in patients with UC and CD and additional 905 healthy 
      individuals (controls). We performed haplotype-based analysis using data from the 
      GWAS and HLA alleles to associate them with UC or CD. RESULTS: The comparative 
      GWAS and the replication study identified significant associations in the major 
      histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 x 
      10(-)(7)(0); odds ratio [OR] = 4.44). Haplotype-based analysis in the major 
      histocompatibility complex region showed that HLA-Cw*1202-B*5201-DRB1*1502 
      haplotype was significantly associated with increased risk of UC compared with CD 
      (P = 1.1 x 10(-)(3)(3); OR = 6.58), accounting for most of the associations observed in 
      the GWAS. Compared with the controls, this HLA haplotype significantly increases 
      susceptibility to UC (P = 4.0 x 10(-)(2)(1); OR = 2.65), but reduces risk for CD (P = 
      1.1 x 10(-)(7); OR = 0.40). Distinct effects of this HLA haplotype on UC and CD were 
      independent of other HLA alleles and haplotypes (P = 2.0 x 10(-)(1)(9) and P = 7.2 x 
      10(-)(5), respectively). CONCLUSIONS: The HLA-Cw*1202-B*5201-DRB1*1502 haplotype 
      increases susceptibility to UC but reduces risk for CD, based on a GWAS of a 
      Japanese population.
CI  - Copyright (c) 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
FAU - Okada, Yukinori
AU  - Okada Y
AD  - Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama 
      Institute, Japan.
FAU - Yamazaki, Keiko
AU  - Yamazaki K
FAU - Umeno, Junji
AU  - Umeno J
FAU - Takahashi, Atsushi
AU  - Takahashi A
FAU - Kumasaka, Natsuhiko
AU  - Kumasaka N
FAU - Ashikawa, Kyota
AU  - Ashikawa K
FAU - Aoi, Tomomi
AU  - Aoi T
FAU - Takazoe, Masakazu
AU  - Takazoe M
FAU - Matsui, Toshiyuki
AU  - Matsui T
FAU - Hirano, Atsushi
AU  - Hirano A
FAU - Matsumoto, Takayuki
AU  - Matsumoto T
FAU - Kamatani, Naoyuki
AU  - Kamatani N
FAU - Nakamura, Yusuke
AU  - Nakamura Y
FAU - Yamamoto, Kazuhiko
AU  - Yamamoto K
FAU - Kubo, Michiaki
AU  - Kubo M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110719
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (HLA-B*52:01 antigen)
RN  - 0 (HLA-B52 Antigen)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
CIN - Gastroenterology. 2012 Mar;142(3):e27-8; author reply e28-9. PMID: 22281265
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Colitis, Ulcerative/epidemiology/ethnology/*genetics
MH  - Crohn Disease/epidemiology/ethnology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - HLA-B52 Antigen/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2011/06/28 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/25 06:00
PHST- 2010/12/27 00:00 [received]
PHST- 2011/03/23 00:00 [revised]
PHST- 2011/05/26 00:00 [accepted]
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0016-5085(11)00752-9 [pii]
AID - 10.1053/j.gastro.2011.05.048 [doi]
PST - ppublish
SO  - Gastroenterology. 2011 Sep;141(3):864-871.e1-5. doi: 
      10.1053/j.gastro.2011.05.048. Epub 2011 Jul 19.