PMID- 21701271
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20110624
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 57
IP  - 4
DP  - 2011 Jul-Aug
TI  - Development of endovascular vibrating polymer actuator probe for mechanical 
      thrombolysis: a phantom study.
PG  - 286-92
LID - 10.1097/MAT.0b013e31822188ce [doi]
AB  - In this study, we propose a new method for enhancement of intraarterial 
      thrombolysis using an ionic polymer-metal composite (IPMC) actuator. The purpose 
      of this study was to test the mechanical thrombolysis efficiency of IPMC 
      actuators and evaluate the endovascular vibrating polymer actuator probe for 
      mechanical thrombolysis in a phantom model; 2 x 1 x 15 mm (2 mm in width, 1 mm in 
      thickness, and 15 mm in length) and 0.8 x 0.8 x 10 mm (0.8 mm in width, 0.8 mm in 
      thickness, and 10 mm in length) IPMC actuators were fabricated by stacking five 
      and four Nafion-117 films, respectively. We manufactured the endovascular 
      vibrating polymer actuator probe, for which thrombolysis efficiency was tested in 
      a vascular phantom. The phantom study using 2 x 1 x 15 mm IPMC actuators showed 
      that 5 Hz actuation is the optimal frequency for thrombolysis under both 2 and 3 
      V, when blood clot was not treated with rtPA, and when exposed to rtPA, IPMC 
      actuators under the optimized condition (3 V, 5 Hz, and 5 min) significantly 
      increased the thrombolysis degree compared with control and other experimental 
      groups (p < 0.05). In addition, 0.8 x 0.8 x 10 mm IPMC actuators also revealed a 
      significantly higher thrombolysis degree under the optimized condition than the 
      control and rtPA only groups (p < 0.05). Finally, the fabricated probe using 0.8 
      x 0.8 x 10 mm IPMC actuators also incurred higher thrombolysis degree under the 
      optimized condition than the control and rtPA only groups (p < 0.05). A vibrating 
      polymer actuator probe is a feasible device for intravascular thrombolysis, and 
      further study in an animal model is warranted.
FAU - Choi, Seung Hong
AU  - Choi SH
AD  - Department of Radiology, Seoul National University College of Medicine, 
      Chongno-gu, Seoul, Korea.
FAU - Yoon, Bye-Ri
AU  - Yoon BR
FAU - Oh, Jin Sun
AU  - Oh JS
FAU - Han, Moon Hee
AU  - Han MH
FAU - Lee, Jang Yeol
AU  - Lee JY
FAU - Cho, Hye Rim
AU  - Cho HR
FAU - Kim, Moon June
AU  - Kim MJ
FAU - Rhee, Kyehan
AU  - Rhee K
FAU - Jho, Jae Young
AU  - Jho JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 0 (Ions)
RN  - 0 (Metals)
RN  - 0 (Polymers)
SB  - IM
MH  - Blood Coagulation
MH  - Fistula/pathology
MH  - Hemolysis
MH  - Humans
MH  - Ions/*chemistry
MH  - Materials Testing
MH  - Metals/*chemistry
MH  - Phantoms, Imaging
MH  - Polymers/*chemistry
MH  - Reproducibility of Results
MH  - Thrombolytic Therapy/*methods
MH  - Time Factors
MH  - Vibration
EDAT- 2011/06/28 06:00
MHDA- 2011/10/20 06:00
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - 00002480-201107000-00008 [pii]
AID - 10.1097/MAT.0b013e31822188ce [doi]
PST - ppublish
SO  - ASAIO J. 2011 Jul-Aug;57(4):286-92. doi: 10.1097/MAT.0b013e31822188ce.