PMID- 21703366
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20220318
IS  - 1872-8278 (Electronic)
IS  - 1567-7249 (Linking)
VI  - 11
IP  - 5
DP  - 2011 Sep
TI  - The role of mitochondrial membrane potential in ischemic heart failure.
PG  - 700-6
LID - 10.1016/j.mito.2011.06.001 [doi]
AB  - The molecular events occurring during myocardial infarction and cardioprotection 
      are described with an emphasis on the changes of the mitochondrial membrane 
      potential (DeltaPsi(m)). The low DeltaPsi(m) values of the normal beating heart (100-140 mV) 
      are explained by the allosteric ATP-inhibition of cytochrome c oxidase (CcO) 
      through feedback inhibition by ATP at high [ATP]/[ADP] ratios. During ischemia 
      the mechanism is reversibly switched off by signaling through reactive oxygen 
      species (ROS). At reperfusion high DeltaPsi(m) values cause a burst of ROS production 
      leading to apoptosis and/or necrosis. Ischemic preconditioning is suggested to 
      cause additional phosphorylation of CcO, protecting the enzyme from immediate 
      dephosphorylation via ROS signaling.
CI  - Copyright (c) 2011 (c) Elsevier B.V. and Mitochondria Research Society. All rights 
      reserved. Published by Elsevier B.V. All rights reserved.
FAU - Kadenbach, Bernhard
AU  - Kadenbach B
AD  - Fachbereich Chemie, Philipps-Universitaet, D-35032 Marburg, Germany. 
      kadenbach@staff.uni-marburg.de
FAU - Ramzan, Rabia
AU  - Ramzan R
FAU - Moosdorf, Rainer
AU  - Moosdorf R
FAU - Vogt, Sebastian
AU  - Vogt S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110616
PL  - Netherlands
TA  - Mitochondrion
JT  - Mitochondrion
JID - 100968751
RN  - 0 (Reactive Oxygen Species)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Allosteric Regulation
MH  - Animals
MH  - Cytoprotection
MH  - Electron Transport Complex IV/antagonists & inhibitors/metabolism
MH  - Heart Failure/*metabolism/physiopathology
MH  - Humans
MH  - *Membrane Potential, Mitochondrial
MH  - Mitochondria, Heart/metabolism/pathology
MH  - Myocardial Ischemia/*metabolism/physiopathology
MH  - Myocardial Reperfusion Injury/metabolism/physiopathology
MH  - Oxygen Consumption
MH  - Permeability
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction
EDAT- 2011/06/28 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/28 06:00
PHST- 2011/03/23 00:00 [received]
PHST- 2011/05/13 00:00 [revised]
PHST- 2011/06/08 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1567-7249(11)00223-6 [pii]
AID - 10.1016/j.mito.2011.06.001 [doi]
PST - ppublish
SO  - Mitochondrion. 2011 Sep;11(5):700-6. doi: 10.1016/j.mito.2011.06.001. Epub 2011 
      Jun 16.