PMID- 21704765
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20220330
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 699
IP  - 1
DP  - 2011 Aug 5
TI  - Determination of N-methylcarbamate insecticides in water samples using dispersive 
      liquid-liquid microextraction and HPLC with the aid of experimental design and 
      desirability function.
PG  - 113-9
LID - 10.1016/j.aca.2011.04.011 [doi]
AB  - A rapid and simple method for the extraction and preconcentration of 
      N-methylcarbamates (NMCs) (carbofuran, carbaryl and promecarb) in water samples 
      using dispersive liquid-liquid microextraction (DLLME) using chemometrics was 
      developed. Influence variables such as volume of extracting (CHCl(3)) and 
      dispersing solvents (ACN), pH and ionic strength, extraction time and 
      centrifugation time and speed were screened in a 2(7-4) Plackett-Burman design 
      was investigated. The significant variables were optimized by using a central 
      composite design (CCD) combined with desirability function (DF). At optimum 
      conditions values of variables set as 126 muL chloroform, 1.5 mL acetonitrile, 1 
      min extraction time, 10 min centrifugation at 4000 rpm min(-1), natural pH, 4.7% 
      (w/v) NaCl, the separation was reached in less than 14 min using a C(18) column 
      and an isocratic binary mobile phase (acetonitrile: water (50:50, v/v)) with flow 
      rate of 1.0 mL min(-1). At optimum conditions method has linear response over 
      0.001-10 mug mL(-1) with detection limit between 0.0001 and 0.0005 mug mL(-1) with 
      relative standard deviations (RSDs) in the range 2.18-5.06% (n=6).
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Khodadoust, Saeid
AU  - Khodadoust S
AD  - Department of Chemistry, University of Mazandaran, Babolsar, Iran. 
      saeid.kh64@gmail.com
FAU - Hadjmohammadi, Mohammadreza
AU  - Hadjmohammadi M
LA  - eng
PT  - Journal Article
DEP - 20110416
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Carbamates)
RN  - 0 (Insecticides)
RN  - 0 (Solvents)
RN  - 0 (Water Pollutants, Chemical)
RN  - 1QRP20775S (promecarb)
RN  - 6414-57-9 (N-methylcarbamate)
RN  - R890C8J3N1 (Carbaryl)
RN  - SKF77S6Y67 (Carbofuran)
SB  - IM
MH  - Carbamates/*analysis/isolation & purification
MH  - Carbaryl/analysis/isolation & purification
MH  - Carbofuran/analysis/isolation & purification
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Hydrogen-Ion Concentration
MH  - Insecticides/*analysis/isolation & purification
MH  - Osmolar Concentration
MH  - Research Design
MH  - Solvents/chemistry
MH  - Water Pollutants, Chemical/*analysis/isolation & purification
EDAT- 2011/06/28 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/03/24 00:00 [revised]
PHST- 2011/04/10 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0003-2670(11)00533-2 [pii]
AID - 10.1016/j.aca.2011.04.011 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2011 Aug 5;699(1):113-9. doi: 10.1016/j.aca.2011.04.011. Epub 
      2011 Apr 16.