PMID- 21708203
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20211203
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 9
DP  - 2011 Sep
TI  - Diversity distributions of killer cell immunoglobulin-like receptor genes and 
      their ligands in the Chinese Shaanxi Han population.
PG  - 733-40
LID - 10.1016/j.humimm.2011.04.003 [doi]
AB  - In the present study, 17 killer cell immunoglobulin-like receptors (KIR) genes 
      and KIR ligands (human leukocyte antigen [HLA] -A and -B) were detected by using 
      a polymerase chain reaction-sequence-specific primer (PCR-SSP) method in 104 
      unrelated healthy Han individuals living in Shaanxi province, China. The observed 
      carrier frequencies of the 12 KIR genes ranged from 0.14 to 0.96. KIR2DL4, 3DL2, 
      3DL3, 2DP1 and 3DP1 were found to be present in every individual. A total of 51 
      different KIR gene profiles were identified, in which 11 gene profiles 
      exclusively belonged to the study population. Neighbor-joining phylogenetic tree 
      between the studing population and its neighboring ethnic groups was constructed 
      using the observed carrier frequencies of 13 KIR loci. The phylogenetic tree 
      shows that the Shaanxi Han population, Han populations in different regions, Yi, 
      Japanese, and Koreans were in the same cluster. KIR/HLA relationships show that 
      KIR3DS1(-)/3DL1(+)/Bw4(+) was the most common association in the population. In 
      conclusion, the present study findings reveal the high polymorphism of KIRs in 
      the Shaanxi Han population, demonstrate the KIR/HLA association in the study 
      population, and enrich the KIR and HLA gene resources. The obtained KIR data will 
      further the understanding of genetic relationships among populations in different 
      geographic areas, and assist in answering questions regarding KIR/HLA 
      relationships.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Wang, Hong-dan
AU  - Wang HD
AD  - Key Laboratory of Environment and Gene Related to Diseases (Xi'an Jiaotong 
      University), Ministry of Education, Xi'an, Shaanxi, China.
FAU - Zhu, Bo-feng
AU  - Zhu BF
FAU - Shen, Chun-mei
AU  - Shen CM
FAU - Fan, Ai-ying
AU  - Fan AY
FAU - Song, Tie-niu
AU  - Song TN
FAU - Liu, Jia-li
AU  - Liu JL
FAU - Qin, Hai-xia
AU  - Qin HX
FAU - Deng, Li-bin
AU  - Deng LB
FAU - Fan, Shuan-liang
AU  - Fan SL
FAU - Huang, Qi-zhao
AU  - Huang QZ
FAU - Guo, You-feng
AU  - Guo YF
FAU - Fang, Jie
AU  - Fang J
FAU - Zhang, Ping
AU  - Zhang P
FAU - Yan, Chun-xia
AU  - Yan CX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110612
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - China
MH  - *Ethnicity
MH  - Gene Frequency
MH  - Genetics, Population
MH  - Genotyping Techniques
MH  - HLA-A Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Phylogeny
MH  - Polymorphism, Genetic
MH  - Receptors, KIR/*genetics
EDAT- 2011/06/29 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/06/29 06:00
PHST- 2010/10/19 00:00 [received]
PHST- 2011/04/01 00:00 [revised]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - S0198-8859(11)00093-0 [pii]
AID - 10.1016/j.humimm.2011.04.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Sep;72(9):733-40. doi: 10.1016/j.humimm.2011.04.003. Epub 2011 
      Jun 12.