PMID- 2171045
OWN - NLM
STAT- MEDLINE
DCOM- 19901109
LR  - 20191210
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 29
IP  - 2-3
DP  - 1990 Jul 30
TI  - The amino acid sequence of chymodenin, a hormone-like peptide from porcine 
      duodenum, is identical to cytochrome C-oxidase, peptide VII.
PG  - 241-50
AB  - The amino acid sequence of chymodenin, a hormone-like peptide from porcine 
      duodenum is reported. The molecule is known to rapidly alter the proportions of 
      digestive enzymes secreted by the rabbit pancreas in vivo and in vitro, by 
      selection of the specific intra-pancreatic source from which the preset mixture 
      of digestive enzymes is secreted. The sequence is identical to that of cytochrome 
      C-oxidase peptide VII (cCoVII) from bovine heart, with the exception of a 
      substitution of threonine for alanine at position 6 and a second substitution of 
      alanine for threonine at position 71. Disulfide bridges link positions 29-64 and 
      39-53. cCoVII-chymodenin has a pentapeptide (-Ala-Glu-Gly-Thr-Phe-) near the 
      carboxy-terminus which is immediately preceded by an -Arg-Arg- sequence in the 
      porcine and bovine sequences of cCoVII. This peptide is identical to a 
      pentapeptide found close to the amino terminus of the hormones gastric inhibitory 
      peptide (GIP) and glucagon-like peptide I. The identity to cCoVII means 
      chymodenin as isolated is itself unlikely to be a gastrointestinal hormone. 
      However, the partial commonality of sequence with the glucagon-secretin family 
      immediately adjacent to a pro-hormone-like activation site, and the specific 
      actions on the exocrine pancreas, means that the molecule probably mimics the 
      natural actions of an as-yet uncharacterized member of the glucagon family, which 
      exerts a unique action on exocrine pancreatic secretion.
FAU - Bennett, H P
AU  - Bennett HP
AD  - Endocrine Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada.
FAU - Chang, R Y
AU  - Chang RY
FAU - Nelbach, L
AU  - Nelbach L
FAU - Adelson, J W
AU  - Adelson JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Gastrointestinal Hormones)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides)
RN  - 52350-18-2 (chymodenin)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Duodenum/chemistry
MH  - Electron Transport Complex IV/*chemistry
MH  - Gastrointestinal Hormones/*chemistry
MH  - Intercellular Signaling Peptides and Proteins
MH  - Molecular Sequence Data
MH  - Peptide Fragments/*chemistry
MH  - Peptides/*chemistry
MH  - Swine
EDAT- 1990/07/30 00:00
MHDA- 1990/07/30 00:01
CRDT- 1990/07/30 00:00
PHST- 1990/07/30 00:00 [pubmed]
PHST- 1990/07/30 00:01 [medline]
PHST- 1990/07/30 00:00 [entrez]
AID - 0167-0115(90)90086-C [pii]
AID - 10.1016/0167-0115(90)90086-c [doi]
PST - ppublish
SO  - Regul Pept. 1990 Jul 30;29(2-3):241-50. doi: 10.1016/0167-0115(90)90086-c.