PMID- 21711933
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2045-3701 (Electronic)
IS  - 2045-3701 (Linking)
VI  - 1
IP  - 1
DP  - 2011 May 24
TI  - Role of dendritic cells in the induction of regulatory T cells.
PG  - 20
LID - 10.1186/2045-3701-1-20 [doi]
AB  - Dendritic cells (DCs) play a key role in initiating immune responses and 
      maintaining immune tolerance. In addition to playing a role in thymic selection, 
      DCs play an active role in tolerance under steady state conditions through 
      several mechanisms which are dependent on IL-10, TGF-beta, retinoic acid, 
      indoleamine-2,3,-dioxygenase along with vitamin D. Several of these mechanisms 
      are employed by DCs in induction of regulatory T cells which are comprised of Tr1 
      regulatory T cells, natural and inducible foxp3+ regulatory T cells, Th3 
      regulatory T cells and double negative regulatory T cells. It appears that 
      certain DC subsets are highly specialized in inducing regulatory T cell 
      differentiation and in some tissues the local microenvironment plays a role in 
      driving DCs towards a tolerogenic response. In this review we discuss the recent 
      advances in our understanding of the mechanisms underlying DC driven regulatory T 
      cell induction.
FAU - Kushwah, Rahul
AU  - Kushwah R
AD  - Physiology and Experimental Medicine Research Program, Hospital for Sick 
      Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada. 
      Jim.Hu@utoronto.ca.
FAU - Hu, Jim
AU  - Hu J
LA  - eng
PT  - Journal Article
DEP - 20110524
PL  - England
TA  - Cell Biosci
JT  - Cell & bioscience
JID - 101561195
PMC - PMC3125210
EDAT- 2011/06/30 06:00
MHDA- 2011/06/30 06:01
PMCR- 2011/05/24
CRDT- 2011/06/30 06:00
PHST- 2011/01/31 00:00 [received]
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/06/30 06:01 [medline]
PHST- 2011/05/24 00:00 [pmc-release]
AID - 2045-3701-1-20 [pii]
AID - 10.1186/2045-3701-1-20 [doi]
PST - epublish
SO  - Cell Biosci. 2011 May 24;1(1):20. doi: 10.1186/2045-3701-1-20.