PMID- 21712058
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 1
DP  - 2012 Jan
TI  - Common and well-documented (CWD) alleles of human leukocyte antigen-A, -B, -C, 
      -DRB1, and -DQB1 loci for the Chinese Han population do not quite correlate with 
      the ASHI CWD alleles.
PG  - 61-6
LID - 10.1016/j.humimm.2011.06.005 [doi]
AB  - Human leukocyte antigen (HLA), which is extremely polymorphic, plays an important 
      role in stem cell transplantation. The Chinese Han comprise a large population of 
      approximately 1.3 billion with diverse HLA alleles that need to be characterized. 
      Data from 3,296 independent, unrelated Chinese Han individuals (1,457 recipients 
      and 1,839 donors) were provided by the China Marrow Donor Program (CMDP) for 
      donor-recipient confirmatory typing. Sequence-based typing, sequence-specific 
      oligonucleotide probe (SSOP)/High Definition-SSOP, and sequence-specific primer 
      methods were used to obtain 4-digit alleles. A total of 49, 86, 50, 63, and 24 
      HLA-A, -B, -C, -DRB1, and -DQB1 alleles were observed. Following American Society 
      for Histocompatibility and Immunogenetics (ASHI) common and well-documented (CWD) 
      criteria, CWD alleles for Chinese Han in our laboratory test and other laboratory 
      reports do not quite correlate with the ASHI CWD alleles: A*11:53, A*02:34, 
      A*02:53N, B*27:24, B*46:02, B*55:12, C*01:06, C*03:17, C*06:06, C*07:66, C*07:67, 
      C*08:22, DRB1*12:10, DQB1*03:13, and DQB1*06:05 are CWD, but are not included in 
      the ASHI CWD list. A series of alleles are well-documented alleles and are listed 
      in the ASHI CWD list. Conversely, A*26:03, B*51:03, C*12:05, C*15:09, C*15:11, 
      C*17:03, DRB1*11:07, DRB1*11:11, DRB1*13:05, DRB1*13:13, DRB1*14:06, DRB1*14:12, 
      DRB1*14:22, DRB1*14:25, and DQB1*06:11 are rare alleles, but are included in the 
      ASHI CWD list. HLA ethnic diversity is the main reason for the differences in HLA 
      alleles worldwide. The ASHI HLA CWD alleles help reduce the workload and expenses 
      in high-resolution donor registries and the HLA allele frequencies provide a 
      basis from which to predict the chances of finding HLA matching donors. Our data 
      will be meaningful for the CMDP, for other worldwide donor registries, and for an 
      updated ASHI CWD allele list.
CI  - Copyright (c) 2012 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - He, Jun
AU  - He J
AD  - First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People's 
      Republic of China. junhe1964@163.com
FAU - Li, Yang
AU  - Li Y
FAU - Bao, Xiaojing
AU  - Bao X
FAU - Qiu, Qiaocheng
AU  - Qiu Q
FAU - Yuan, Xiaoni
AU  - Yuan X
FAU - Xu, Chao
AU  - Xu C
FAU - Shen, Jiehong
AU  - Shen J
FAU - Hou, Jianquan
AU  - Hou J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110615
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
CIN - Hum Immunol. 2012 Jan;73(1):60. PMID: 22056614
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Gene Frequency
MH  - Genetics, Population
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Histocompatibility/genetics/immunology
MH  - Humans
MH  - Immunogenetics/organization & administration/statistics & numerical data
EDAT- 2011/06/30 06:00
MHDA- 2012/05/19 06:00
CRDT- 2011/06/30 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2011/06/02 00:00 [revised]
PHST- 2011/06/07 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - S0198-8859(11)00149-2 [pii]
AID - 10.1016/j.humimm.2011.06.005 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 Jan;73(1):61-6. doi: 10.1016/j.humimm.2011.06.005. Epub 2011 
      Jun 15.