PMID- 21712061
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20121115
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 49
IP  - 9
DP  - 2011 Sep
TI  - Protective activity of the Uncaria tomentosa extracts on human erythrocytes in 
      oxidative stress induced by 2,4-dichlorophenol (2,4-DCP) and catechol.
PG  - 2202-11
LID - 10.1016/j.fct.2011.06.013 [doi]
AB  - The purpose of this study was to evaluate the effect of the ethanolic and aqueous 
      extracts of Uncaria tomentosa on human erythrocytes and additionally the 
      assessment of protective effect of these extracts on hemolysis induction, 
      hemoglobin oxidation, and changes in the level of reactive oxygen species (ROS) 
      and lipid peroxidation, which were provoked by selected xenobiotics, i.e. 
      2,4-dichlorophenol (2,4-DCP) and catechol. All tested extracts, even at a very 
      high concentration of 500 mug/ml were not toxic to the erythrocytes because they 
      did not cause lipid peroxidation, increase methemoglobin and ROS levels nor 
      provoked hemolysis. The results of this study also revealed protective effect of 
      extracts of U. tomentosa. The extracts studied depleted the extent of hemoglobin 
      oxidation and lipid peroxidation as well as decreased the level of ROS and 
      hemolysis, which was provoked by 2,4-DCP. No protective activity of the extracts 
      against catechol action, which is a precursor of semiquinones in cell was found. 
      A difference in the effect of the extracts studied was observed. Ethanol-based 
      extracts revealed more pronounced ability to inhibit oxidation processes in human 
      erythrocytes.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bors, Milena
AU  - Bors M
AD  - Department of Biophysics of Environmental Pollution, University of Lodz, Pomorska 
      141/143 Str., 90-237 Lodz, Poland.
FAU - Bukowska, Bozena
AU  - Bukowska B
FAU - Pilarski, Radoslaw
AU  - Pilarski R
FAU - Gulewicz, Krzysztof
AU  - Gulewicz K
FAU - Oszmianski, Jan
AU  - Oszmianski J
FAU - Michalowicz, Jaromir
AU  - Michalowicz J
FAU - Koter-Michalak, Maria
AU  - Koter-Michalak M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110625
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Catechols)
RN  - 0 (Chlorophenols)
RN  - 0 (Plant Extracts)
RN  - LF3AJ089DQ (catechol)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Cat's Claw/*chemistry
MH  - Catechols/*pharmacology
MH  - Chlorophenols/*toxicity
MH  - Chromatography, High Pressure Liquid
MH  - Erythrocytes/*drug effects
MH  - Flow Cytometry
MH  - Humans
MH  - *Oxidative Stress
MH  - Plant Extracts/*pharmacology
EDAT- 2011/06/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/30 06:00
PHST- 2011/02/03 00:00 [received]
PHST- 2011/05/19 00:00 [revised]
PHST- 2011/06/03 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0278-6915(11)00257-2 [pii]
AID - 10.1016/j.fct.2011.06.013 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2011 Sep;49(9):2202-11. doi: 10.1016/j.fct.2011.06.013. Epub 
      2011 Jun 25.