PMID- 21712920
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-598X (Electronic)
IS  - 0970-2113 (Print)
IS  - 0970-2113 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Apr
TI  - Can bronchial asthma be classified based on the immunological status?
PG  - 110-3
LID - 10.4103/0970-2113.80323 [doi]
AB  - BACKGROUND: Bronchial asthma is a chronic disorder of the airways. Bronchial 
      asthma can be broadly categorized into atopic and nonatopic based on the 
      immunological status, which may be helpful to plan appropriate treatment. In this 
      study, the cytokine profile of the blood was estimated to evaluate the difference 
      between the atopic and the nonatopic asthmatics. AIM: The aim was to document the 
      differences in cytokine (IL-6, TNF-alpha, and IFN-gamma) imbalance in asthmatics with 
      high serum immunoglobulin E (IgE) levels compared to those with normal serum IgE. 
      MATERIALS AND METHODS: Thirty confirmed bronchial asthmatics (17 men, 13 women) 
      were included in this study. The serum levels of IgE, IFN-gamma TNF-alpha, and IL-6 were 
      measured using the enzyme-linked immunosorbent assay technique. They were divided 
      into two groups based on serum IgE: asthmatics with normal serum IgE levels as 
      group A (n = 7) and high IgE levels as group B (n = 23). RESULTS: : The 
      differences in the mean values of IgE, TNF-alpha, and IFN-gamma were statistically 
      significant between the groups. These values were significantly higher in group B 
      compared to group A. IL-6 was not significantly different between the groups. In 
      group A, IL-6 was negatively correlated with IgE and IFN-gamma. IgE and IFN-gamma were 
      positively correlated. In group B, IFN-gamma and TNF-alpha showed a high correlation of 
      +0.93. CONCLUSION: Two groups of asthmatics stratified according to their serum 
      IgE levels were immunologically different showing different profiles of serum 
      cytokine levels and the relationship between the cytokines.
FAU - Subrahmanyam, Roopakala Mysore
AU  - Subrahmanyam RM
AD  - Department of Physiology, M. S. Ramaiah Medical College and Teaching Hospital, 
      Bangalore, Karnataka, India.
FAU - Srikantaiah, Chandrashekara
AU  - Srikantaiah C
FAU - Krishna, Pushpa
AU  - Krishna P
FAU - Delphine Silvia, Chickbllapur Rayappa Wilma
AU  - Delphine Silvia CR
FAU - Thirunavukkarasu, Sandeep
AU  - Thirunavukkarasu S
FAU - Devi, Kusuma
AU  - Devi K
FAU - Rao, Mohan
AU  - Rao M
FAU - Kumar, Vasantha
AU  - Kumar V
LA  - eng
PT  - Journal Article
PL  - India
TA  - Lung India
JT  - Lung India : official organ of Indian Chest Society
JID - 8405380
PMC - PMC3109832
OTO - NOTNLM
OT  - Bronchial asthma
OT  - correlation
OT  - cytokines
OT  - immunoglobulin E
COIS- Conflict of Interest: None declared
EDAT- 2011/06/30 06:00
MHDA- 2011/06/30 06:01
PMCR- 2011/04/01
CRDT- 2011/06/30 06:00
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/06/30 06:01 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - LI-28-110 [pii]
AID - 10.4103/0970-2113.80323 [doi]
PST - ppublish
SO  - Lung India. 2011 Apr;28(2):110-3. doi: 10.4103/0970-2113.80323.