PMID- 21713583
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211020
IS  - 1433-0407 (Electronic)
IS  - 0028-2804 (Linking)
VI  - 83
IP  - 7
DP  - 2012 Jul
TI  - [Structural and functional neuronal connectivity in Alzheimer's disease: a 
      combined DTI and fMRI study].
PG  - 878-87
LID - 10.1007/s00115-011-3326-3 [doi]
AB  - BACKGROUND: Cognitive performance depends on intact cortical connectivity. 
      Important for memory processing in the human brain is the connection between 
      posterior cingulate cortex and hippocampus, directly as well as indirectly via 
      the parahippocampal gyrus. These brain areas are involved early in Alzheimer's 
      disease (AD). At the same time, they belong to the default mode network (DMN), a 
      functional network showing high functional connectivity under resting state 
      conditions. In AD, this connectivity in specifically compromised, offering the 
      possibility to investigate the structural basis of functional brain connectivity. 
      METHODS: We studied 18 patients with mild to moderate AD, 16 patients with mild 
      cognitive impairment (MCI) and 20 healthy control subjects using diffusion tensor 
      imaging (DTI) and resting state fMRI at 3.0 Tesla. We determined the effect of 
      structural integrity in the posterior cingulate as assessed by DTI on the 
      functional connectivity between posterior cingulate, hippocampus and 
      parahippocampus during resting state in these three groups. RESULTS: Structural 
      integrity was reduced in posterior cingulate fibre tracts in patients with AD in 
      the left hemisphere; however, this effect was partly accounted for by age 
      differences. All three groups showed high functional connectivity between 
      posterior cingulate cortex and hippocampus, via both the direct and the indirect 
      pathways. Determination of effective connectivity yielded a negative fractional 
      anisotropy (FA)-moderated correlation on the direct pathway in AD and MCI for 
      both hemispheres, and in healthy controls for the right hemisphere. The indirect 
      pathway showed a negative FA-moderated correlation in AD for the right hemisphere 
      and in MCI for both hemispheres. Healthy controls showed a positive correlation 
      on the indirect pathway for the left hemisphere. CONCLUSION: Our data suggest 
      that under healthy conditions, effective connectivity in the DMN between 
      posterior cingulate cortex and hippocampus is mainly maintained by the indirect 
      pathway via the parahippocampal gyrus. Patients with AD and patients with MCI 
      show changes in this connectivity with a partial allocation to the direct 
      pathway, most likely reflecting early parahippocampal lesions. The combination of 
      DTI and fMRI broadens our understanding of human brain connectivity and its 
      pathological changes with AD.
FAU - Soldner, J
AU  - Soldner J
AD  - Alzheimer Gedachtniszentrum, Klinik und Poliklinik fur Psychiatrie und 
      Psychotherapie, Ludwig-Maximilians-Universitat Munchen, Munchen, Deutschland.
FAU - Meindl, T
AU  - Meindl T
FAU - Koch, W
AU  - Koch W
FAU - Bokde, A L W
AU  - Bokde AL
FAU - Reiser, M F
AU  - Reiser MF
FAU - Moller, H-J
AU  - Moller HJ
FAU - Burger, K
AU  - Burger K
FAU - Hampel, H
AU  - Hampel H
FAU - Teipel, S J
AU  - Teipel SJ
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Strukturelle und funktionelle neuronale Konnektivitat bei der Alzheimer-Krankheit 
      : Eine kombinierte DTI- und fMRT-Studie.
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*pathology/*physiopathology
MH  - Brain/*pathology/*physiopathology
MH  - Diffusion Magnetic Resonance Imaging/methods
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*pathology/*physiopathology
MH  - Neural Pathways/pathology/physiopathology
MH  - Neuroimaging/*methods
MH  - Subtraction Technique
EDAT- 2011/06/30 06:00
MHDA- 2012/12/12 06:00
CRDT- 2011/06/30 06:00
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1007/s00115-011-3326-3 [doi]
PST - ppublish
SO  - Nervenarzt. 2012 Jul;83(7):878-87. doi: 10.1007/s00115-011-3326-3.