PMID- 21713603
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20211020
IS  - 1437-7772 (Electronic)
IS  - 1341-9625 (Linking)
VI  - 17
IP  - 3
DP  - 2012 Jun
TI  - Patterns of recurrence and outcome in patients with surgically resected small 
      cell lung cancer.
PG  - 218-24
LID - 10.1007/s10147-011-0277-4 [doi]
AB  - BACKGROUND: Although prophylactic cranial irradiation (PCI) in limited-stage (LS) 
      small cell lung cancer (SCLC) patients who are surgically resected and treated 
      with adjuvant chemotherapy is considered to be a reasonable treatment option, the 
      efficacy of PCI for those patients remains unclear. METHODS: The records of 28 
      patients with SCLC undergoing curative surgery at the Aichi Cancer Center 
      Hospital between 1995 and March 2008 were retrospectively reviewed to assess 
      patterns of relapse and overall survival. RESULTS: The patients were 27 men and 1 
      woman. Eight patients underwent induction chemotherapy. Fourteen patients (50%) 
      had pathologic stage (p-stage) I disease, 7 patients (25%) had p-stage II, and 7 
      patients (25%) had p-stage III. Nineteen patients underwent adjuvant chemotherapy 
      and one patient received adjuvant chemoradiotherapy. There were a total of 13 
      deaths and 8 were disease-related. Most patients developed hematogenous distant 
      metastases before their death. The 5-year overall probability of survival was 
      47%. Ten (36%) of the 28 patients had a relapse. Two had a local relapse alone, 
      one patient had combined local and distant relapses, and seven patients had 
      distant metastases alone as their first site of failure. Four patients with 
      p-stage II/III disease developed brain metastases with a cumulative incidence at 
      1 and 2 years of 25 and 36%, respectively. CONCLUSIONS: Our retrospective study 
      suggested that PCI might have a role in surgically resected patients with p-stage 
      II/III SCLC because of their relatively high frequency of brain metastasis.
FAU - Ogawa, Shizu
AU  - Ogawa S
AD  - Department of Thoracic Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, 
      Chikusa-ku, Nagoya, 464-8681, Japan.
FAU - Horio, Yoshitsugu
AU  - Horio Y
FAU - Yatabe, Yasusi
AU  - Yatabe Y
FAU - Fukui, Takayuki
AU  - Fukui T
FAU - Ito, Simon
AU  - Ito S
FAU - Hasegawa, Yoshinori
AU  - Hasegawa Y
FAU - Mitsudomi, Tetsuya
AU  - Mitsudomi T
FAU - Hida, Toyoaki
AU  - Hida T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110630
PL  - Japan
TA  - Int J Clin Oncol
JT  - International journal of clinical oncology
JID - 9616295
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/prevention & control/secondary
MH  - Chemoradiotherapy
MH  - Combined Modality Therapy
MH  - Cranial Irradiation
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/pathology/*surgery/therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Radiotherapy, Adjuvant
MH  - Retrospective Studies
MH  - Small Cell Lung Carcinoma/pathology/*surgery/therapy
MH  - Treatment Outcome
EDAT- 2011/06/30 06:00
MHDA- 2013/07/23 06:00
CRDT- 2011/06/30 06:00
PHST- 2011/01/18 00:00 [received]
PHST- 2011/06/10 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - 10.1007/s10147-011-0277-4 [doi]
PST - ppublish
SO  - Int J Clin Oncol. 2012 Jun;17(3):218-24. doi: 10.1007/s10147-011-0277-4. Epub 
      2011 Jun 30.