PMID- 21713605
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 219
IP  - 1
DP  - 2012 Jan
TI  - A direct comparison of the behavioral and physiological effects of 
      methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in humans.
PG  - 109-22
LID - 10.1007/s00213-011-2383-4 [doi]
AB  - RATIONALE: Despite their chemical similarities, methamphetamine and 
      3,4-methylenedioxymethamphetamine (MDMA) produce differing neurochemical and 
      behavioral responses in animals. In humans, individual studies of methamphetamine 
      and MDMA indicate that the drugs engender overlapping and divergent effects; 
      there are only limited data comparing the two drugs in the same individuals. 
      OBJECTIVES: This study examined the effects of methamphetamine and MDMA using a 
      within-subject design. METHODS: Eleven adult volunteers completed this 13-day 
      residential laboratory study, which consisted of four 3-day blocks of sessions. 
      On the first day of each block, participants received oral methamphetamine (20, 
      40 mg), MDMA (100 mg), or placebo. Drug plasma concentrations, cardiovascular, 
      subjective, and cognitive/psychomotor performance effects were assessed before 
      drug administration and after. Food intake and sleep were also assessed. On 
      subsequent days of each block, placebo was administered and residual effects were 
      assessed. RESULTS: Acutely, both drugs increased cardiovascular measures and 
      "positive" subjective effects and decreased food intake. In addition, when asked 
      to identify each drug, participants had difficulty distinguishing between the 
      amphetamines. The drugs also produced divergent effects: methamphetamine improved 
      performance and disrupted sleep, while MDMA increased "negative" 
      subjective-effect ratings. Few residual drug effects were noted for either drug. 
      CONCLUSIONS: It is possible that the differences observed could explain the 
      differential public perception and abuse potential associated with these 
      amphetamines. Alternatively, the route of administration by which the drugs are 
      used recreationally might account for the many of the effects attributed to these 
      drugs (i.e., MDMA is primarily used orally, whereas methamphetamine is used by 
      routes associated with higher abuse potential).
FAU - Kirkpatrick, Matthew G
AU  - Kirkpatrick MG
AD  - Department of Psychology, Columbia University, New York, NY, USA.
FAU - Gunderson, Erik W
AU  - Gunderson EW
FAU - Perez, Audrey Y
AU  - Perez AY
FAU - Haney, Margaret
AU  - Haney M
FAU - Foltin, Richard W
AU  - Foltin RW
FAU - Hart, Carl L
AU  - Hart CL
LA  - eng
GR  - K05 DA031749/DA/NIDA NIH HHS/United States
GR  - DA-03746/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110630
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Cognition/*drug effects/physiology
MH  - Eating/*drug effects/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Methamphetamine/*administration & dosage
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Psychomotor Performance/*drug effects/physiology
MH  - Sleep/*drug effects/physiology
MH  - Young Adult
PMC - PMC4430833
MID - NIHMS687472
EDAT- 2011/06/30 06:00
MHDA- 2012/09/21 06:00
PMCR- 2015/05/14
CRDT- 2011/06/30 06:00
PHST- 2011/02/03 00:00 [received]
PHST- 2011/06/10 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PHST- 2015/05/14 00:00 [pmc-release]
AID - 10.1007/s00213-011-2383-4 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2012 Jan;219(1):109-22. doi: 
      10.1007/s00213-011-2383-4. Epub 2011 Jun 30.