PMID- 21714909
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20211020
IS  - 1471-2202 (Electronic)
IS  - 1471-2202 (Linking)
VI  - 12
DP  - 2011 Jun 29
TI  - Cortical gene transcription response patterns to water maze training in aged 
      mice.
PG  - 63
LID - 10.1186/1471-2202-12-63 [doi]
AB  - BACKGROUND: The hippocampus mediates the acquisition of spatial memory, but the 
      memory trace is eventually transferred to the cortex. We have investigated 
      transcriptional activation of pathways related to cognitive function in the 
      cortex of the aged mouse by analyzing gene expression following water maze 
      training. RESULTS: We identified genes that were differentially responsive in 
      aged mice with accurate spatial performance during probe trials or repeated 
      swimming sessions, relative to home cage conditions. Effective learners exhibited 
      significantly greater activation of several pathways, such as the 
      mitogen-activated protein kinase and insulin receptor signaling pathways, 
      relative to swimmers. The genes encoding activity-related cytoskeletal protein 
      (Arc) and brain-derived neurotrophic factor (BDNF) were upregulated in proficient 
      learners, relative to swimmers and home cage controls, while the gene encoding 
      Rho GTPase activating protein 32 (GRIT) was downregulated. We explored the 
      regulation of Arc, BDNF, and GRIT expression in greater morphological detail 
      using in situ hybridization. Recall during probe trials enhanced Arc expression 
      across multiple cortical regions involved in the cognitive component of water 
      maze learning, while BDNF expression was more homogeneously upregulated across 
      cortical regions involved in the associational and sensorimotor aspects of water 
      maze training. In contrast, levels of GRIT expression were uniformly reduced 
      across all cortical regions examined. CONCLUSIONS: These results suggest that 
      cortical gene transcription is responsive to learning in aged mice that exhibit 
      behavioral proficiency, and support a distributed hypothesis of memory storage 
      across multiple cortical compartments.
FAU - Park, Sung-Soo
AU  - Park SS
AD  - Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, 
      USA.
FAU - Stranahan, Alexis M
AU  - Stranahan AM
FAU - Chadwick, Wayne
AU  - Chadwick W
FAU - Zhou, Yu
AU  - Zhou Y
FAU - Wang, Liyun
AU  - Wang L
FAU - Martin, Bronwen
AU  - Martin B
FAU - Becker, Kevin G
AU  - Becker KG
FAU - Maudsley, Stuart
AU  - Maudsley S
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110629
PL  - England
TA  - BMC Neurosci
JT  - BMC neuroscience
JID - 100966986
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Age Factors
MH  - Aging/*physiology
MH  - Animals
MH  - Cerebral Cortex/*metabolism
MH  - Gene Expression Regulation/*physiology
MH  - Male
MH  - Maze Learning/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Transcription Factors/*metabolism
PMC - PMC3142531
EDAT- 2011/07/01 06:00
MHDA- 2012/03/21 06:00
PMCR- 2011/06/29
CRDT- 2011/07/01 06:00
PHST- 2011/01/19 00:00 [received]
PHST- 2011/06/29 00:00 [accepted]
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
PHST- 2011/06/29 00:00 [pmc-release]
AID - 1471-2202-12-63 [pii]
AID - 10.1186/1471-2202-12-63 [doi]
PST - epublish
SO  - BMC Neurosci. 2011 Jun 29;12:63. doi: 10.1186/1471-2202-12-63.