PMID- 2171522
OWN - NLM
STAT- MEDLINE
DCOM- 19901121
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 172
IP  - 1
DP  - 1990 Oct 15
TI  - The interaction of a c-Jun/Fos related protein factor with the U3 sequences of 
      the mouse mammary tumor virus LTR.
PG  - 348-56
AB  - Using polyacrylamide gel mobility shift assay we have detected a nuclear factor 
      (NF-S) in a mouse mammary tumor cell line (GR) that binds to an upstream sequence 
      domain (-766 to -737) near the 5'-end of the mouse mammary tumor virus (MMTV) 
      long terminal repeat (LTR). Antibodies to the products of the Jun and Fos 
      oncogenes interfered with the binding potential of this factor, indicating that 
      the factor shares antigenic determinants with c-Jun/AP-1. In vitro translated 
      c-Jun and c-Fos were also found to bind to the NF-S binding domain consisting of 
      the sequence TGA(A/G)TCA that are known to be recognized by c-Jun/AP-1. Our 
      results raise the possibility that the MMTV-LTR sequence element-766 to -737 by 
      interacting with a Jun/Fos related protein play a role in MMTV transcription 
      and/or the activation of int protooncogenes that are associated with murine 
      mammary tumorigenesis.
FAU - Siddique, H R
AU  - Siddique HR
AD  - Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 
      30912-2100.
FAU - Sarkar, N H
AU  - Sarkar NH
LA  - eng
GR  - CA-45123/CA/NCI NIH HHS/United States
GR  - CA-45127/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Oligonucleotide Probes)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - Cell Nucleus/metabolism
MH  - DNA-Binding Proteins/*metabolism
MH  - Mammary Glands, Animal/metabolism
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Mutagenesis, Site-Directed
MH  - Oligonucleotide Probes
MH  - Protein Biosynthesis
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-fos
MH  - Proto-Oncogene Proteins c-jun
MH  - *Repetitive Sequences, Nucleic Acid
MH  - Restriction Mapping
MH  - Sequence Homology, Nucleic Acid
MH  - Transcription Factors/*metabolism
EDAT- 1990/10/15 00:00
MHDA- 1990/10/15 00:01
CRDT- 1990/10/15 00:00
PHST- 1990/10/15 00:00 [pubmed]
PHST- 1990/10/15 00:01 [medline]
PHST- 1990/10/15 00:00 [entrez]
AID - S0006-291X(05)80216-5 [pii]
AID - 10.1016/s0006-291x(05)80216-5 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1990 Oct 15;172(1):348-56. doi: 
      10.1016/s0006-291x(05)80216-5.