PMID- 2171558
OWN - NLM
STAT- MEDLINE
DCOM- 19901214
LR  - 20220419
IS  - 0268-8697 (Print)
IS  - 0268-8697 (Linking)
VI  - 4
IP  - 4
DP  - 1990
TI  - The clinical, radiological and histopathological features of cerebral primitive 
      neuroectodermal tumours.
PG  - 287-97
AB  - The clinical, radiological and pathological features of eight cases of 
      supratentorial primitive neuroectodermal tumour are reviewed. These are tumours 
      of children and young adults presenting with symptoms and signs of raised 
      intracranial pressure. Radiologically they are characterized by a large enhancing 
      mass lesion exciting little or modest surrounding oedema, with a propensity to 
      develop in the frontal lobes. One tumour exhibited the pathological features of a 
      primitive neuroectodermal tumour (PNET) with ependymal differentiation 
      (ependymoblastoma). The rest showed no light microscopy patterns to indicate 
      differentiation. Immunohistochemistry was helpful as it excluded other causes of 
      a 'small blue cell' tumour but did not help in assessing differentiation. 
      Ultrastructural examination of this group of apparently undifferentiated tumours 
      showed focal markers of neuronal differentiation. Although features of neuronal 
      differentiation can be found ultrastructurally in these tumours this is only 
      evident after prolonged searching, often of several blocks, making assessment 
      very prone to sampling errors. The term PNET thus remains appropriate and serves 
      to group such tumours together to facilitate rational clinical management.
FAU - Pigott, T J
AU  - Pigott TJ
AD  - Department of Neurosurgery, University Hospital, Nottingham, United Kingdom.
FAU - Punt, J A
AU  - Punt JA
FAU - Lowe, J S
AU  - Lowe JS
FAU - Henderson, M J
AU  - Henderson MJ
FAU - Beck, A
AU  - Beck A
FAU - Gray, T
AU  - Gray T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
SB  - IM
MH  - Adult
MH  - Cell Differentiation
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Ependymoma/pathology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Neoplasms, Germ Cell and Embryonal/diagnostic imaging/pathology/*surgery
MH  - Neurons/pathology
MH  - Supratentorial Neoplasms/diagnostic imaging/pathology/*surgery
MH  - Tomography, X-Ray Computed
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.3109/02688699008992738 [doi]
PST - ppublish
SO  - Br J Neurosurg. 1990;4(4):287-97. doi: 10.3109/02688699008992738.