PMID- 21718399
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20171116
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 65
IP  - 9
DP  - 2011 Sep
TI  - Current benign prostatic hyperplasia treatment: impact on sexual function and 
      management of related sexual adverse events.
PG  - 1005-13
LID - 10.1111/j.1742-1241.2011.02731.x [doi]
AB  - Benign prostatic hyperplasia (BPH) is a common disease in older men that can lead 
      to lower urinary tract symptoms (LUTS). Male sexual dysfunction is also an 
      age-related condition. Epidemiological studies have confirmed an association 
      between BPH/LUTS and sexual dysfunction in ageing men that is independent of the 
      effects of age, other co-morbidities and lifestyle factors. Proposed 
      pathophysiological mechanisms for BPH/LUTS-associated sexual dysfunction include 
      the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway, rho-kinase and 
      endothelin-1 activity, autonomic nervous system overactivity and the metabolic 
      syndrome, and pelvic organ atherosclerosis. Both BPH/LUTS and sexual dysfunction 
      can have a substantial negative impact on a man's quality of life. However, 
      urologists and primary care physicians appear to under-recognise sexual 
      dysfunction in men with BPH/LUTS. Current guidelines recommend alpha-blockers and 
      5-alpha reductase inhibitors, either alone or in combination, among appropriate 
      medical treatment options for BPH/LUTS. Randomised, controlled trials demonstrate 
      that these therapies can be associated with sexual adverse effects (AEs) such as 
      loss of libido, erectile dysfunction and ejaculatory disorders. Sexual 
      dysfunction should be fully evaluated in men requiring treatment for BPH/LUTS 
      using validated questionnaires. Management of sexual dysfunction in men treated 
      for BPH/LUTS should involve assessment of co-morbidities and concomitant 
      medications, consideration of lifestyle interventions such as weight loss and 
      increased physical activity to improve risk factors and, if necessary, 
      introduction of pharmacotherapies. In addition, physicians should provide 
      patients with proper counselling on the possible sexual AEs of medical therapies 
      for BPH/LUTS and their impact on sexual satisfaction, while being aware of the 
      possibility that counselling in itself is likely to influence reported rates of 
      sexual dysfunction.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Mirone, V
AU  - Mirone V
AD  - Department of Urology, University Federico II of Naples, Naples, Italy. 
      mirone@unina.it
FAU - Sessa, A
AU  - Sessa A
FAU - Giuliano, F
AU  - Giuliano F
FAU - Berges, R
AU  - Berges R
FAU - Kirby, M
AU  - Kirby M
FAU - Moncada, I
AU  - Moncada I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110701
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (5-alpha Reductase Inhibitors)
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Drug Combinations)
RN  - 0 (Endothelin-1)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 2.7.11.1 (rho-Associated Kinases)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - 5-alpha Reductase Inhibitors/therapeutic use
MH  - Adrenergic alpha-Antagonists/therapeutic use
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/complications
MH  - Autonomic Nervous System Diseases/complications
MH  - Cyclic GMP/metabolism
MH  - Drug Combinations
MH  - Endothelin-1/metabolism
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/complications
MH  - Middle Aged
MH  - Nitric Oxide/metabolism
MH  - Prostatic Hyperplasia/complications/*drug therapy
MH  - Prostatism/*etiology
MH  - Sexual Dysfunction, Physiological/diagnosis/*etiology/therapy
MH  - rho-Associated Kinases/metabolism
EDAT- 2011/07/02 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.1111/j.1742-1241.2011.02731.x [doi]
PST - ppublish
SO  - Int J Clin Pract. 2011 Sep;65(9):1005-13. doi: 10.1111/j.1742-1241.2011.02731.x. 
      Epub 2011 Jul 1.