PMID- 21718475
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20240406
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 9
DP  - 2011 Jun 30
TI  - Aurora Kinase A expression is associated with lung cancer histological-subtypes 
      and with tumor de-differentiation.
PG  - 100
LID - 10.1186/1479-5876-9-100 [doi]
AB  - BACKGROUND: Aurora kinase A (AURKA) is a member of serine/threonine kinase 
      family. Several kinases belonging to this family are activated in the G2/M phase 
      of the cell cycle being involved in mitotic chromosomal segregation. AURKA 
      overexpression is significantly associated with neoplastic transformation in 
      several tumors and deregulated Aurora Kinases expression leads to chromosome 
      instability, thus contributing to cancer progression. The purpose of the present 
      study was to investigate the expression of AURKA in non small cell lung cancer 
      (NSCLC) specimens and to correlate its mRNA or protein expression with patients' 
      clinico-pathological features. MATERIALS AND METHODS: Quantitative real-time PCR 
      and immunohistochemistry analysis on matched cancer and corresponding normal 
      tissues from surgically resected non-small cell lung cancers (NSCLC) have been 
      performed aiming to explore the expression levels of AURKA gene. RESULTS: AURKA 
      expression was significantly up-modulated in tumor samples compared to matched 
      lung tissue (p<0.01, mean log2(FC)=1.5). Moreover, AURKA was principally 
      up-modulated in moderately and poorly differentiated lung cancers (p<0.01), as 
      well as in squamous and adenocarcinomas compared to the non-invasive 
      bronchioloalveolar histotype (p=0.029). No correlation with survival was 
      observed. CONCLUSION: These results indicate that in NSCLC AURKA over-expression 
      is restricted to specific subtypes and poorly differentiated tumors.
FAU - Lo Iacono, Marco
AU  - Lo Iacono M
AD  - Department of Clinical and Biological Sciences, University of Turin, Turin, 
      Italy. marco.loiacono@unito.it
FAU - Monica, Valentina
AU  - Monica V
FAU - Saviozzi, Silvia
AU  - Saviozzi S
FAU - Ceppi, Paolo
AU  - Ceppi P
FAU - Bracco, Enrico
AU  - Bracco E
FAU - Papotti, Mauro
AU  - Papotti M
FAU - Scagliotti, Giorgio V
AU  - Scagliotti GV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110630
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.1 (AURKA protein, human)
RN  - EC 2.7.11.1 (Aurora Kinase A)
RN  - EC 2.7.11.1 (Aurora Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aurora Kinase A
MH  - Aurora Kinases
MH  - Carcinoma, Non-Small-Cell Lung/classification/enzymology/genetics/pathology
MH  - *Cell Dedifferentiation
MH  - Cell Movement
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/classification/*enzymology/genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Protein Serine-Threonine Kinases/genetics/*metabolism
MH  - RNA, Messenger/genetics/metabolism
PMC - PMC3148570
EDAT- 2011/07/02 06:00
MHDA- 2011/12/13 00:00
PMCR- 2011/06/30
CRDT- 2011/07/02 06:00
PHST- 2010/10/07 00:00 [received]
PHST- 2011/06/30 00:00 [accepted]
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2011/06/30 00:00 [pmc-release]
AID - 1479-5876-9-100 [pii]
AID - 10.1186/1479-5876-9-100 [doi]
PST - epublish
SO  - J Transl Med. 2011 Jun 30;9:100. doi: 10.1186/1479-5876-9-100.