PMID- 21718910
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20220410
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 58
IP  - 2
DP  - 2011 Jul 5
TI  - Impaired fasting glucose and the risk of incident diabetes mellitus and 
      cardiovascular events in an adult population: MESA (Multi-Ethnic Study of 
      Atherosclerosis).
PG  - 140-6
LID - 10.1016/j.jacc.2011.03.025 [doi]
AB  - OBJECTIVES: The purpose of the study was to assess the cardiovascular risk of 
      impaired fasting glucose (IFG). BACKGROUND: The associations between IFG, 
      incident type 2 diabetes mellitus (T2DM), and cardiovascular (CV) events remains 
      unclear. METHODS: The MESA (Multi-Ethnic Study of Atherosclerosis) study included 
      participants who were 45 to 84 years or age and free of clinical CV disease at 
      baseline (2000 to 2002). Type 2 DM was defined as fasting glucose >125 mg/dl or 
      receiving antidiabetes medication at baseline and follow-up examinations; IFG was 
      defined as no T2DM and fasting glucose 100 to 125 mg/dl. Cox proportional hazards 
      analysis was used to assess the association between IFG and incident DM and also 
      between IFG and incident CV events. RESULTS: Of 6,753 participants included in 
      these analyses, 840 (12.7%) had T2DM and 940 (13.8%) had IFG at the baseline 
      examination. During 7.5 years of follow-up, there were 418 adjudicated CV events. 
      Type 2 DM was associated with an increased CV incidence in the univariate model 
      (hazard ratio [HR]: 2.83, 95% confidence interval [CI]: 2.25 to 3.56, p < 0.0001) 
      and multivariate model adjusted for demographics and traditional risk factors 
      (HR: 1.87, 95% CI: 1.47 to 2.37, p < 0.0001) compared with subjects not having 
      T2DM (IFG plus normal fasting glucose). Impaired fasting glucose was associated 
      with increased incidence of T2DM (HR: 13.2, 95% CI: 10.8 to 16.2, p < 0.001) that 
      remained after adjusting for demographics, highest educational level, physical 
      activity, and body mass index (HR: 10.5, 95% CI: 8.4 to 13.1, p < 0.001) compared 
      with normal fasting glucose. Impaired fasting glucose was associated with 
      incident CV events in the univariate model (HR: 1.64, 95% CI: 1.26 to 2.14, p < 
      0.001) but not in the full multivariate model (HR: 1.16, 95% CI: 0.88 to 1.52, p 
      = 0.3) compared with normal fasting glucose. CONCLUSIONS: Having IFG was not 
      independently associated with an increased short-term risk for incident CV 
      events. These data reiterate the importance of intervention for persons with IFG 
      to reduce their incidence of T2DM.
CI  - Copyright (c) 2011 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Yeboah, Joseph
AU  - Yeboah J
AD  - Department of Internal Medicine/Cardiology, University of Virginia School of 
      Medicine, Charlottesville, Virginia 22908, USA. jy5y@hscmail.mcc.virginia.edu
FAU - Bertoni, Alain G
AU  - Bertoni AG
FAU - Herrington, David M
AU  - Herrington DM
FAU - Post, Wendy S
AU  - Post WS
FAU - Burke, Gregory L
AU  - Burke GL
LA  - eng
GR  - N01-HC-95162/HC/NHLBI NIH HHS/United States
GR  - T32 HL076132/HL/NHLBI NIH HHS/United States
GR  - N01-HC-95163/HC/NHLBI NIH HHS/United States
GR  - T32 HL076132-08/HL/NHLBI NIH HHS/United States
GR  - N01-HC-95159/HC/NHLBI NIH HHS/United States
GR  - N01-HC-95165/HC/NHLBI NIH HHS/United States
GR  - N01HC95159/HL/NHLBI NIH HHS/United States
GR  - N01-HC-95160/HC/NHLBI NIH HHS/United States
GR  - N01HC95167/HL/NHLBI NIH HHS/United States
GR  - N01-HC-95161/HC/NHLBI NIH HHS/United States
GR  - N01-HC-95167/HC/NHLBI NIH HHS/United States
GR  - N01-HC-95164/HC/NHLBI NIH HHS/United States
GR  - N01HC95165/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
RN  - 0 (Blood Glucose)
SB  - IM
CIN - J Am Coll Cardiol. 2011 Dec 6;58(24):2546-7; author reply 2547. PMID: 22133860
MH  - Aged
MH  - Aged, 80 and over
MH  - Atherosclerosis/complications/*diagnosis/*ethnology/therapy
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Cardiovascular Diseases/complications/*diagnosis/ethnology
MH  - Diabetes Complications
MH  - Diabetes Mellitus/*diagnosis
MH  - Ethnicity
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Risk
PMC - PMC3146297
MID - NIHMS309307
EDAT- 2011/07/02 06:00
MHDA- 2011/09/07 06:00
PMCR- 2012/07/05
CRDT- 2011/07/02 06:00
PHST- 2011/01/14 00:00 [received]
PHST- 2011/03/02 00:00 [revised]
PHST- 2011/03/22 00:00 [accepted]
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
PHST- 2012/07/05 00:00 [pmc-release]
AID - S0735-1097(11)01402-1 [pii]
AID - 10.1016/j.jacc.2011.03.025 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2011 Jul 5;58(2):140-6. doi: 10.1016/j.jacc.2011.03.025.