PMID- 21719014
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20131121
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 219
IP  - 1
DP  - 2011 Nov
TI  - Effect of phytosterols and their oxidation products on lipoprotein profiles and 
      vascular function in hamster fed a high cholesterol diet.
PG  - 124-33
LID - 10.1016/j.atherosclerosis.2011.06.004 [doi]
AB  - Human diets contain phytosterols and their oxidation products. We investigated 
      effect of beta-sitosterol (Si), stigmasterol (St), beta-sitosterol oxidation products 
      (SiOP) and stigmasterol oxidation products (StOP) on plasma total cholesterol and 
      their interaction with the gene expression of enzymes, proteins and transporters 
      involved in cholesterol absorption and metabolism. Sixty male hamsters were fed 
      the control diet or one of four experimental diets containing 0.1% Si, 0.1% SiOP, 
      0.1% St and 0.1% StOP, respectively, for six weeks. SiOP and StOP groups had the 
      relative liver weights greater than their corresponding non-oxidized forms, 
      indicating they were possibly toxic. Results showed both Si and St groups reduced 
      while SiOP and StOP hamsters lost the capacity of lowering plasma total 
      cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triacylglycerols 
      (TG) compared with the control group. Si and St but not SiOP and StOP were 
      anti-atherosclerotic. RT-PCR analysis demonstrated Si and St but not SiOP and 
      StOP down-regulated mRNA levels of intestinal acyl CoA: cholesterol 
      acyltransferase (ACAT2) and microsomal triglyceride protein (MTP). Aortas from Si 
      and St hamsters relaxed better than those from the control and their 
      corresponding SiOP and StOP-treated hamsters. It was concluded that Si and St not 
      SiOP and StOP were beneficial in improving lipoprotein profile and aortic 
      function.
CI  - Copyright A(c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Liang, Yin Tong
AU  - Liang YT
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China.
FAU - Wong, Wing Tak
AU  - Wong WT
FAU - Guan, Lei
AU  - Guan L
FAU - Tian, Xiao Yu
AU  - Tian XY
FAU - Ma, Ka Ying
AU  - Ma KY
FAU - Huang, Yu
AU  - Huang Y
FAU - Chen, Zhen-Yu
AU  - Chen ZY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110613
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Lipoproteins)
RN  - 0 (Sitosterols)
RN  - 0 (Triglycerides)
RN  - 5LI01C78DD (gamma-sitosterol)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 99WUK5D0Y8 (Stigmasterol)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/drug effects/*physiology
MH  - Cholesterol/blood/*metabolism
MH  - Cholesterol, Dietary/administration & dosage/*pharmacology
MH  - Cricetinae
MH  - Lipoproteins/*blood
MH  - Liver/anatomy & histology/drug effects/metabolism
MH  - Male
MH  - Mesocricetus
MH  - Organ Size
MH  - Oxidation-Reduction
MH  - Plaque, Atherosclerotic/pathology
MH  - Sitosterols/metabolism/*pharmacology
MH  - Stigmasterol/metabolism/*pharmacology
MH  - Triglycerides/blood
MH  - Vasoconstriction/drug effects
MH  - Vasodilation/drug effects
EDAT- 2011/07/02 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/05/23 00:00 [revised]
PHST- 2011/06/02 00:00 [accepted]
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0021-9150(11)00481-3 [pii]
AID - 10.1016/j.atherosclerosis.2011.06.004 [doi]
PST - ppublish
SO  - Atherosclerosis. 2011 Nov;219(1):124-33. doi: 
      10.1016/j.atherosclerosis.2011.06.004. Epub 2011 Jun 13.