PMID- 21720681
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20170123
IS  - 0717-6287 (Electronic)
IS  - 0716-9760 (Linking)
VI  - 44
IP  - 1
DP  - 2011
TI  - Contribution of dendritic cell/T cell interactions to triggering and maintaining 
      autoimmunity.
PG  - 53-61
LID - 10.4067/S0716-97602011000100007 [doi]
AB  - Under healthy conditions, there is a balance between tolerance to self-tissue 
      constituents and immunity against foreign antigens. Autoimmunity diseases (AD) 
      take place when that equilibrium is disrupted and the immune response is directed 
      to self-antigens, leading to injury or destruction of host tissues. The 
      mechanisms conducing to the loss of immune tolerance remain largely unknown. The 
      recent appearance of biological therapies has contributed to significant 
      reduction in morbidity. However, currently available therapies are associated 
      with important side effects and work only as palliative treatments. Dendritic 
      cells (DCs) have emerged as key players in developing and maintaining adaptive 
      immunity due to their capacity to prime and modulate T cell function. Therefore, 
      because DCs work as central modulators of immune tolerance, it is likely that 
      alterations in their function can lead to the onset of autoimmune-inflammatory 
      diseases. By modulating DC function, novel pathways in antigen-specific tolerance 
      could be established. In this article, the possible contribution of altered DC-T 
      cell interactions to the onset of autoimmunity are discussed. In addition, we 
      expand on the notion that some of the functions of these cells could be relevant 
      targets for intervening therapies aimed to restore the balance or even prevent 
      the loss of tolerance.
FAU - Llanos, Carolina
AU  - Llanos C
AD  - Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Pontificia Universidad Catolica de Chile.
FAU - Carreno, Leandro J
AU  - Carreno LJ
FAU - Kalergis, Alexis M
AU  - Kalergis AM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110511
PL  - England
TA  - Biol Res
JT  - Biological research
JID - 9308271
SB  - IM
MH  - Autoimmune Diseases/*immunology
MH  - Autoimmunity/*immunology
MH  - Cell Communication/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - T-Lymphocytes/*immunology
EDAT- 2011/07/02 06:00
MHDA- 2012/07/03 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - S0716-97602011000100007 [pii]
AID - 10.4067/S0716-97602011000100007 [doi]
PST - ppublish
SO  - Biol Res. 2011;44(1):53-61. doi: 10.4067/S0716-97602011000100007. Epub 2011 May 
      11.