PMID- 2172133
OWN - NLM
STAT- MEDLINE
DCOM- 19901205
LR  - 20181217
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 22
IP  - 8
DP  - 1990 Aug
TI  - Dietary treatment ameliorates overt diabetes and decreased insulin secretion to 
      glucose, induced by overeating in impaired glucose tolerant mice.
PG  - 408-12
AB  - Overt diabetes (NIDDM) was induced by overeating in neonatally streptozocin (60 
      mg/kg.BW) treated impaired glucose tolerant mice. We imposed a food restriction 
      and a high fiber diet to evaluate the effects of dietary treatment in this NIDDM 
      model mouse. Furthermore, insulin secretion after the dietary treatment was 
      studied using the perfused pancreas technique. One group of IGT mice (SZ) was 
      maintained on ordinary mouse chow during 6 to 14 weeks of age. The others 
      received a cookie and chocolate mashed diet (C.C. diet) to induce overt diabetes 
      during 6 to 10 weeks of age. Thereafter, the mice with induced overt diabetes 
      were divided according to their diet treatment. The C.C. diet was continued in 
      one group (SZC) for 4 weeks, and the others were divided into a food restriction 
      group (SZR: 4 g/mouse/day of ordinary mouse chow, for 4 weeks) and a high fiber 
      diet group (SZF: 20% W/W of cellulose in ordinary mouse chow, for 8 weeks). The 
      mean caloric intake/mouse/day in SZC, SZR and SZF were 140, 80 and 98% of that in 
      SZ, respectively. Amelioration of hyperglycemia and impaired glucose tolerance 
      was noted in SZR and SZF. A better glycemic control was obtained in SZF with 
      keeping a normal growth rate. On the pancreas perfusion, the insulin secretion to 
      30 mM glucose was improved in SZR and SZF. Furthermore, the incremental first 
      phase peak insulin release to 30 mM glucose in SZF was significantly greater than 
      that in SZC (SZF, 10.5 +/- 1.0 vs. SZC, 4.5 +/- 1.9 microU/min).(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Hasegawa, G
AU  - Hasegawa G
AD  - First Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
FAU - Mori, H
AU  - Mori H
FAU - Sawada, M
AU  - Sawada M
FAU - Takagi, S
AU  - Takagi S
FAU - Shigeta, H
AU  - Shigeta H
FAU - Kitagawa, Y
AU  - Kitagawa Y
FAU - Nakano, K
AU  - Nakano K
FAU - Kanatsuna, T
AU  - Kanatsuna T
FAU - Kondo, M
AU  - Kondo M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fiber)
RN  - 0 (Insulin)
RN  - 94ZLA3W45F (Arginine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Arginine/pharmacology
MH  - Blood Glucose/metabolism
MH  - Body Weight
MH  - Diabetes Mellitus, Experimental/*diet therapy/metabolism/psychology
MH  - Diet
MH  - Dietary Fiber/pharmacology
MH  - Eating/*physiology
MH  - Glucose/*pharmacology
MH  - Glucose Tolerance Test
MH  - Insulin/*metabolism
MH  - Insulin Secretion
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Pancreas/metabolism
MH  - Perfusion
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
AID - 10.1055/s-2007-1004935 [doi]
PST - ppublish
SO  - Horm Metab Res. 1990 Aug;22(8):408-12. doi: 10.1055/s-2007-1004935.