PMID- 21721906
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20131121
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 34
IP  - 1
DP  - 2012 Feb
TI  - Carbon tetrachloride: a hepatotoxin causes oxidative stress in murine peritoneal 
      macrophage and peripheral blood lymphocyte cells.
PG  - 157-62
LID - 10.3109/08923973.2011.590498 [doi]
AB  - CONTEXT: Carbon tetrachloride (CCl(4)) is frequently used as a chemical inducer of 
      tissue damage. Their effects on mouse peritoneal macrophages and also in 
      peripheral blood lymphocytes are still unknown. OBJECTIVE: Therefore we tried to 
      focus on intracellular oxidative stress produced by CCl(4) in mouse macrophage and 
      lymphocyte cells. METHODS: Intraperitoneal administration of CCl(4) induces 
      intracellular superoxide anions production in mouse macrophages and peripheral 
      blood lymphocytes and leads a subsequent lipid peroxidation and protein 
      oxidation. N-acetyl cystein (NAC) and vitamin C were administered 
      intraperitoneally at a dose of 150 mg/kg and their effect on demodulating the 
      oxidative stress is also checked. RESULT AND DISCUSSION: Several in vitro 
      approaches have already been established as a free radical scavenging models, but 
      this free radical screening models is not always correlated with the in vivo 
      screening models. NAC and vitamin C were administered intraperitoneally and 
      significant reduction of the oxidative stress in term of scavenging of toxic 
      superoxide anion observed in both the macrophages and lymphocytes. CONCLUSION: 
      Therefore we are hopeful that our work will light a new insight into the 
      screening of in vivo free radical scavenging model for evaluating 
      anti-inflammatory compounds.
FAU - Bala, Asis
AU  - Bala A
AD  - Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur 
      University, Kolkata,West Bengal, India. asisbala_ju@yahoo.co.in
FAU - Haldar, Pallab Kanti
AU  - Haldar PK
FAU - Kar, Biswakanth
AU  - Kar B
FAU - Naskar, Sagar
AU  - Naskar S
FAU - Mazumder, Upal Kanti
AU  - Mazumder UK
LA  - eng
PT  - Journal Article
DEP - 20110701
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Free Radical Scavengers)
RN  - 11062-77-4 (Superoxides)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/pharmacology
MH  - Animals
MH  - Ascorbic Acid/pharmacology
MH  - Carbon Tetrachloride/*toxicity
MH  - Carbon Tetrachloride Poisoning/*metabolism/pathology
MH  - Free Radical Scavengers/pharmacology
MH  - Lipid Peroxidation/drug effects
MH  - Lymphocytes/*metabolism/pathology
MH  - Macrophages, Peritoneal/*metabolism/pathology
MH  - Mice
MH  - Oxidative Stress/*drug effects
MH  - Superoxides/metabolism
EDAT- 2011/07/05 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 10.3109/08923973.2011.590498 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2012 Feb;34(1):157-62. doi: 
      10.3109/08923973.2011.590498. Epub 2011 Jul 1.