PMID- 21722181
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20211203
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 27
IP  - 1
DP  - 2012 Jan
TI  - Mitigating endoplasmic reticulum stress with revaprazan ameliorates 
      stress-related mucosal disease.
PG  - 120-9
LID - 10.1111/j.1440-1746.2011.06838.x [doi]
AB  - BACKGROUND AND AIM: The term "stress-related mucosal disease" (SRMD) represents 
      conditions ranging from superficial mucosal damage to focal deep mucosal damage 
      in the stomach, of which pathogenesis is deduced to be violent mucosal ischemia 
      or excess oxidative stress, but not fully clarified yet. Under the hypothesis 
      that mucosal cell apoptosis subsequent to endoplasmic reticulum (ER) stress might 
      play a crucial role, we evaluated the efficacy and mechanism that novel acid pump 
      antagonist (APA), revaprazan, alleviated water immersion restraint stress (WIRS) 
      induced SRMD in rats. METHODS: In order to define whether WIRS-induced SRMD is 
      associated with ER stress, we checked the alteration in the expression of ER 
      stress markers including GRP78, CHOP, XBP-1, BiP as well as apoptosis in 
      WIRS-induced SRMD. The efficacy of revaprazan on either alleviating ER stress or 
      attenuating SRMD was compared with proton pump inhibitor (PPI) and 
      gastroprotectant. RESULTS: Ten hours of WIRS induced a severe degree of SRMD, in 
      which ER stress markers including CHOP, XBP1, and BiP were significantly 
      overexpressed in the gastric tissues. However, these markers of ER stress were 
      significantly decreased in the group pretreated with revaprazan compared to PPI 
      or gastroprotectant, accompanied with a significant reduction in apoptotic index. 
      In addition to ER stress, revaprazan imposed anti-inflammatory benefit to limit 
      SRMD based on significant levels of inflammatory cell apoptosis. CONCLUSION: 
      Endoplasmic reticulum stress accompanied with drastic apoptosis was implicated in 
      the development of SRMD, but revaprazan could rescue the stomach from SRMD 
      through alleviating ER stress in epithelial cells much better than either PPI or 
      gastroprotectant.
CI  - (c) 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell 
      Publishing Asia Pty Ltd.
FAU - Kim, Jung Ho
AU  - Kim JH
AD  - Department of Gastroenterology Gil Medical Center, Gachon Graduate School of 
      Medicine, Incheon, Korea.
FAU - Kim, Eun Hee
AU  - Kim EH
FAU - Ock, Chanyoung
AU  - Ock C
FAU - Hong, Hua
AU  - Hong H
FAU - Kim, Yoon Jae
AU  - Kim YJ
FAU - Kwon, Kwang An
AU  - Kwon KA
FAU - Park, Dong Kyun
AU  - Park DK
FAU - Hahm, Ki Baik
AU  - Hahm KB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Ddit3 protein, rat)
RN  - 0 (Endoplasmic Reticulum Chaperone BiP)
RN  - 0 (GRP78 protein, rat)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Hspa5 protein, mouse)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Pyrimidinones)
RN  - 0 (Regulatory Factor X Transcription Factors)
RN  - 0 (Tetrahydroisoquinolines)
RN  - 0 (Transcription Factors)
RN  - 0 (X-Box Binding Protein 1)
RN  - 0 (Xbp1 protein, mouse)
RN  - 0 (Xbp1 protein, rat)
RN  - 147336-12-7 (Transcription Factor CHOP)
RN  - 4DQ6T10R64 (YH 1885)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Line
MH  - Cytoprotection
MH  - DNA-Binding Proteins/metabolism
MH  - Disease Models, Animal
MH  - Endoplasmic Reticulum/*drug effects/metabolism
MH  - Endoplasmic Reticulum Chaperone BiP
MH  - Gastric Mucosa/*drug effects/immunology/metabolism/pathology
MH  - Heat-Shock Proteins/metabolism
MH  - Immersion
MH  - Inflammation Mediators/metabolism
MH  - Metabolic Detoxication, Phase II
MH  - Mice
MH  - Proton Pump Inhibitors/*pharmacology
MH  - Pyrimidinones/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Regulatory Factor X Transcription Factors
MH  - Severity of Illness Index
MH  - Stomach Diseases/*drug therapy/etiology/immunology/metabolism/pathology
MH  - Stress, Physiological/*drug effects
MH  - Stress, Psychological/*complications
MH  - Tetrahydroisoquinolines/*pharmacology
MH  - Time Factors
MH  - Transcription Factor CHOP/metabolism
MH  - Transcription Factors/metabolism
MH  - X-Box Binding Protein 1
EDAT- 2011/07/05 06:00
MHDA- 2012/05/12 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - 10.1111/j.1440-1746.2011.06838.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2012 Jan;27(1):120-9. doi: 
      10.1111/j.1440-1746.2011.06838.x.