PMID- 21722544
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20161125
IS  - 1603-9629 (Electronic)
IS  - 0907-8916 (Linking)
VI  - 58
IP  - 7
DP  - 2011 Jul
TI  - Promising results after percutaneous mitral valve repair.
PG  - A4299
AB  - INTRODUCTION: Mitral valve regurgitation (MR) is the secondmost frequent valve 
      disease in Europe. Untreated MR causes considerable morbidity and mortality. In 
      the elderly, as many as half of these patients are denied surgery because of an 
      estimated high surgical risk. Percutaneous mitral valve repair with the MitraClip 
      system resembles the Alfieristitch where a clip is used to connect the tip of the 
      mitral valve leaflets. MATERIAL AND METHODS: Sixteen patients with MR of various 
      origins (functional/degenerative) were treated with the MitraClip system. All 
      patients were highly symptomatic with dyspnoea (New York Heart Association (NYHA) 
      grade three) and MR grade three or more, and had been turned down for surgery due 
      to an excessively high risk. RESULTS: MR was reduced in all but one patient, 
      generally from grade 3.5+/-0.5 to grade 1.4+/-0.9. A total of four patients (25%) 
      received two clips. Thirty-day complications were as follows: one patient died, 
      one had a stroke (speech sequelae), one patient had a new chord rupture that was 
      treated surgically. During 90 days of follow-up, symptoms of dyspnoea diminished 
      (reduction of 1 NYHA grade) and the 6-minute walk test results improved from 
      171+/-99 to 339+/-134 metres (p<0.001). CONCLUSION: Percutaneous mitral valve repair 
      with the MitraClip system is now available in Denmark. The treatment is a 
      reasonable alternative in patients with MR and a high estimated surgery risk. 
      FUNDING: Not relevant. TRIAL REGISTRATION: Not relevant.
FAU - Ihlemann, Nikolaj
AU  - Ihlemann N
AD  - Department of Cardiology, Hjertemedicinsk Klinik B, Rigshospitalet, 2100 
      Copenhagen, Denmark. ihlemann@gmail.com
FAU - Franzen, Olaf
AU  - Franzen O
FAU - Jorgensen, Erik
AU  - Jorgensen E
FAU - Hansen, Peter Bo
AU  - Hansen PB
FAU - Hassager, Christian
AU  - Hassager C
FAU - Moller, Jacob Eifer
AU  - Moller JE
FAU - Sondergaard, Lars
AU  - Sondergaard L
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Dan Med Bull
JT  - Danish medical bulletin
JID - 0066040
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty, Balloon, Coronary/*adverse effects/statistics & numerical data
MH  - Cardiomyopathies/diagnostic imaging/surgery/*therapy
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/diagnostic imaging/surgery/*therapy
MH  - Myocardial Ischemia/diagnostic imaging/surgery/therapy
MH  - Prognosis
MH  - Treatment Outcome
MH  - Ultrasonography, Doppler
EDAT- 2011/07/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - A4299 [pii]
PST - ppublish
SO  - Dan Med Bull. 2011 Jul;58(7):A4299.