PMID- 21723144 OWN - NLM STAT- MEDLINE DCOM- 20120130 LR - 20111003 IS - 1096-0023 (Electronic) IS - 1043-4666 (Linking) VI - 56 IP - 2 DP - 2011 Nov TI - Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore. PG - 218-23 LID - 10.1016/j.cyto.2011.05.008 [doi] AB - Allergic diseases affect more than 25% of the world population and result from a complex interplay between genetic and environmental factors. Recent evidence has shown that BDNF (Brain Derived Neurotrophic Factor) could serve as an important marker of allergic disease. Increased levels of BDNF in blood, bronchoalveolar lavage fluid and nasal lavage fluid positively correlate with disease activity and severity in patients with allergic rhinitis (AR), asthma and atopic eczema. However, reports on the association between genetic variation in BDNF and allergic disease have been controversial. This study therefore aims to clarify the relationship between single nucleotide polymorphisms (SNPs) in BDNF and a genetic predisposition to AR and asthma in an ethnic Chinese population of Singapore. Volunteers with a self-reported history of asthma (718 subjects) or a history of AR as determined by a researcher-administered questionnaire (795 subjects) were used in this study, alongside controls with no personal or family history of allergy (717 subjects). The association results identified a significant association for the tagSNP rs10767664 with a significant PDominant=0.0007 and OR=1.3 for AR and PDominant=0.0005 and OR=1.3 for asthma (using a dominant model of association). The haplotype based analysis also identified a significant association further confirming the single SNP association. The SNP rs10767664 is strongly linked (r2=0.95) to the functional polymorphism rs6265 (Val66Met), which has previously been reported to be associated to allergic phenotypes and also shown to affect BDNF expression. BDNF is a therefore a key molecular player in allergy. Further studies on polymorphisms within BDNF may shed light on its role in the pathogenesis of allergic diseases and potentially serve as biomarkers for allergic disease. CI - Copyright (c) 2011 Elsevier Ltd. All rights reserved. FAU - Andiappan, Anand Kumar AU - Andiappan AK AD - Department of Biological Sciences, National University of Singapore, Science Drive 4, Singapore 117543, Singapore. FAU - Parate, Pallavi Nilkanth AU - Parate PN FAU - Anantharaman, Ramani AU - Anantharaman R FAU - Suri, Bani Kaur AU - Suri BK FAU - Wang, De Yun AU - Wang de Y FAU - Chew, Fook Tim AU - Chew FT LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110630 PL - England TA - Cytokine JT - Cytokine JID - 9005353 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Asthma/complications/ethnology/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - China/ethnology MH - Female MH - *Genetic Variation MH - Humans MH - Hypersensitivity/complications/ethnology/*genetics MH - Male MH - Polymorphism, Single Nucleotide MH - Rhinitis/complications/ethnology/*genetics MH - Singapore EDAT- 2011/07/05 06:00 MHDA- 2012/01/31 06:00 CRDT- 2011/07/05 06:00 PHST- 2010/10/08 00:00 [received] PHST- 2011/03/30 00:00 [revised] PHST- 2011/05/10 00:00 [accepted] PHST- 2011/07/05 06:00 [entrez] PHST- 2011/07/05 06:00 [pubmed] PHST- 2012/01/31 06:00 [medline] AID - S1043-4666(11)00159-1 [pii] AID - 10.1016/j.cyto.2011.05.008 [doi] PST - ppublish SO - Cytokine. 2011 Nov;56(2):218-23. doi: 10.1016/j.cyto.2011.05.008. Epub 2011 Jun 30.