PMID- 2172387
OWN - NLM
STAT- MEDLINE
DCOM- 19901204
LR  - 20190903
IS  - 0163-4453 (Print)
IS  - 0163-4453 (Linking)
VI  - 21
IP  - 2
DP  - 1990 Sep
TI  - Clinical and laboratory findings in the Paul-Bunnell negative glandular 
      fever-fatigue syndrome.
PG  - 157-65
AB  - Forty-one patients with recurrent fatigue were studied for evidence of symptom 
      clustering, abnormal laboratory findings and infection with novel viruses. 
      Symptom enquiry and investigations were repeated 4 months later. Four patients 
      were found to have diseases compatible with their symptoms. In those remaining, 
      an initial acute onset of symptoms was associated with an intermittent course, 
      tender glands and a raised number of T suppressor lymphocytes. Raised numbers of 
      T suppressor lymphocytes at follow-up correlated with resolution of symptoms. 
      Antibodies to human herpesvirus 6 (HHV-6) were found in 75% of the patients as 
      compared to 53% of a control group and more patients than controls were strongly 
      seropositive. Some patients with chronic fatigue have a pattern of illness which 
      suggests glandular fever, although acute infection with Epstein-Barr virus (EBV) 
      is not demonstrated. Primary or reactivation infection with HHV-6 may have a role 
      in this syndrome.
FAU - Read, R
AU  - Read R
AD  - Clinical Research Centre, Harrow, Middlesex, U.K.
FAU - Larson, E
AU  - Larson E
FAU - Harvey, J
AU  - Harvey J
FAU - Edwards, A
AU  - Edwards A
FAU - Thomson, B
AU  - Thomson B
FAU - Briggs, M
AU  - Briggs M
FAU - Fox, J
AU  - Fox J
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/*blood
MH  - Fatigue Syndrome, Chronic/*complications/diagnosis/immunology
MH  - Female
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Infectious Mononucleosis/*complications/diagnosis/immunology
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Referral and Consultation
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
AID - 0163-4453(90)91675-4 [pii]
AID - 10.1016/0163-4453(90)91675-4 [doi]
PST - ppublish
SO  - J Infect. 1990 Sep;21(2):157-65. doi: 10.1016/0163-4453(90)91675-4.