PMID- 21724264
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220310
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 118
IP  - 12
DP  - 2011 Dec
TI  - Natural history of drusen morphology in age-related macular degeneration using 
      spectral domain optical coherence tomography.
PG  - 2434-41
LID - 10.1016/j.ophtha.2011.05.008 [doi]
AB  - PURPOSE: To characterize the natural history of drusen using spectral-domain 
      optical coherence tomography (SD-OCT) imaging of eyes from patients with 
      nonexudative age-related macular degeneration (AMD). DESIGN: Prospective, 
      longitudinal, natural history study. PARTICIPANTS: We included 143 eyes of 100 
      patients with at least 6 months of follow-up. METHODS: Patients with drusen 
      secondary to nonexudative AMD were scanned using the Cirrus SD-OCT instrument. 
      Eyes were imaged using the 200 x 200 A-scan raster pattern contained within a 6 x 
      6 mm area. Custom software was used to quantify volumetric changes in drusen over 
      a period of >/= 6 months and for as long as 24 months. Drusen volume and drusen 
      area were measured within circular regions centered at the fovea having diameters 
      of 3 and 5 mm. The measurements were analyzed using a suitable scale 
      transformation. For drusen volume, a cube root transformation strategy was used. 
      MAIN OUTCOME MEASURES: Change in drusen volume and area over time. RESULTS: We 
      analyzed 143 eyes of 100 patients with 69 eyes followed for 6 months, 106 eyes 
      followed for 12 months, 48 eyes followed for 18 months, and 48 eyes followed for 
      24 months. The 3 mm circle baseline drusen volume ranged from 0.0009 to 0.7479 
      mm(3) or 0.10 to 0.91 mm using the cube root scale. On average, drusen volume and 
      drusen area increased over time with the magnitude of the increase dependent on 
      the length of follow-up (P = 0.001, 3 mm circle). In the eyes with a decrease in 
      drusen volume, the magnitude of this decrease was dependent on the baseline 
      drusen volume (P = 0.001, 3 mm circle) and independent of the follow-up interval. 
      After 12 months, drusen volume increased in 48% of eyes, remained stable in 40%, 
      and decreased in 12%. CONCLUSIONS: Imaging with SD-OCT revealed a dynamic, 
      undulating growth pattern for drusen with a tendency for drusen to increase in 
      volume and area over time. An appreciation of the quantitative changes in drusen 
      volume over time using SD-OCT imaging provides a novel strategy for following 
      normal disease progression and for identifying novel clinical trial end points to 
      be used when investigating therapies for the treatment of nonexudative AMD. 
      FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after 
      the references.
CI  - Copyright (c) 2011 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Yehoshua, Zohar
AU  - Yehoshua Z
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, Florida 33136, USA.
FAU - Wang, Fenghua
AU  - Wang F
FAU - Rosenfeld, Philip J
AU  - Rosenfeld PJ
FAU - Penha, Fernando M
AU  - Penha FM
FAU - Feuer, William J
AU  - Feuer WJ
FAU - Gregori, Giovanni
AU  - Gregori G
LA  - eng
GR  - P30 EY014801/EY/NEI NIH HHS/United States
GR  - P30 EY014801-01A1/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110702
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
CIN - Ophthalmology. 2012 Jul;119(7):1501-2; author reply 1502. PMID: 22749098
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Female
MH  - Follow-Up Studies
MH  - Fourier Analysis
MH  - Humans
MH  - Macular Degeneration/complications/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Drusen/etiology/*pathology
MH  - Time Factors
MH  - *Tomography, Optical Coherence
PMC - PMC3189426
MID - NIHMS296356
EDAT- 2011/07/05 06:00
MHDA- 2012/01/27 06:00
PMCR- 2012/12/01
CRDT- 2011/07/05 06:00
PHST- 2011/01/01 00:00 [received]
PHST- 2011/03/23 00:00 [revised]
PHST- 2011/05/04 00:00 [accepted]
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - S0161-6420(11)00432-5 [pii]
AID - 10.1016/j.ophtha.2011.05.008 [doi]
PST - ppublish
SO  - Ophthalmology. 2011 Dec;118(12):2434-41. doi: 10.1016/j.ophtha.2011.05.008. Epub 
      2011 Jul 2.