PMID- 21724347
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20151119
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 4
DP  - 2012 Apr
TI  - Association of platelet-SDF-1 with hemodynamic function and infarct size using 
      cardiac MR in patients with AMI.
PG  - e486-90
LID - 10.1016/j.ejrad.2011.06.019 [doi]
AB  - PURPOSE: Platelet-derived stromal-cell-derived factor-1 (SDF-1) plays an 
      important role in trafficking hematopoetic progenitor cells for tissue 
      regeneration and neovascularisation. The aim was to evaluate platelet-SDF-1 and 
      CD34(+) progenitor cells in patients with acute myocardial infarction (AMI) 
      compared with hemodynamic function and infarct size using late gadolinium 
      enhancement (LGE) cardiac magnetic resonance (CMR) imaging. MATERIALS AND 
      METHODS: We consecutively evaluated 40 patients with AMI, who received coronary 
      angiography for primary coronary intervention. Blood was sampled for flow 
      cytometry to determine mean fluorescence intensity (MFI) of platelet-SDF-1 and 
      for isolation of CD34(+) progenitor cells. 48h and three months after coronary 
      stenting, all patients underwent 1.5T CMR for volumetric assessment and LGE. 
      RESULTS: Patients with enhanced platelet-SDF-1 expression (median>/=68.5MFI) showed 
      a significant amelioration of left ventricular ejection fraction (LVEF) (baseline 
      vs. follow-up mean+/-SD: 45+/-6% vs. 56+/-6%; P=0.018) and of stroke volume 
      (73.1+/-19.1mL vs. 89.9+/-21.3mL; P=0.032) at three-month follow-up in contrast to 
      patients with a decreased platelet-SDF-1 expression level (LVEF: 53+/-8% vs. 
      56+/-10%; P=0.267; stroke volume: 85.6+/-23.1mL vs. 87.4+/-23.2mL; P=0.803). Inversely, 
      LGE infarct size showed significantly reduced in patients with enhanced 
      platelet-SDF-1 expression at three months (18.9+/-12mL vs. 6.3+/-5.1mL; P=0.002) 
      compared to patients with decreased platelet-SDF-1 (12.7+/-12.7mL vs. 7.6+/-8.4mL; 
      P=0.156). Time-dependent autocorrelation coefficients shifted for both SV (lag 1: 
      r=-0.368; P=0.001) and the number of CD34(+) cells (lag 1: r=0.633; P=0.001) to a 
      positive autocorrelation (SV; lag 2: r=0.295; P=0.001; CD34(+) cells; lag 2: 
      r=0.287; P=0.001). Patients with increased number of CD34(+) cells 
      (median>/=420cells/hpf) showed a significant amelioration of stroke volume in 
      three-month follow-up (83.9+/-5.3mL vs. 99.4+/-4.1mL; P=0.020) compared with patients 
      with decreased number of CD34(+) cells (69.3+/-4.1mL vs. 76.1+/-3.2mL; P=0.282). 
      CONCLUSIONS: Platelet-SDF-1 and number of CD34(+) progenitor cells are associated 
      with CMR hemodynamic function in patients with AMI.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Geisler, Tobias
AU  - Geisler T
AD  - Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, 
      Eberhard-Karls-Universitat Tubingen, Germany.
FAU - Fekecs, Lisa
AU  - Fekecs L
FAU - Wurster, Thomas
AU  - Wurster T
FAU - Chiribiri, Amedeo
AU  - Chiribiri A
FAU - Schuster, Andreas
AU  - Schuster A
FAU - Nagel, Eike
AU  - Nagel E
FAU - Miller, Stephan
AU  - Miller S
FAU - Gawaz, Meinrad
AU  - Gawaz M
FAU - Stellos, Konstantinos
AU  - Stellos K
FAU - Bigalke, Boris
AU  - Bigalke B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110702
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Biomarkers)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
SB  - IM
MH  - Biomarkers/blood
MH  - Chemokine CXCL12/*blood
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/complications/*diagnosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
MH  - Ventricular Dysfunction, Left/*blood/*diagnosis/etiology
EDAT- 2011/07/05 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/03/29 00:00 [received]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - S0720-048X(11)00558-4 [pii]
AID - 10.1016/j.ejrad.2011.06.019 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Apr;81(4):e486-90. doi: 10.1016/j.ejrad.2011.06.019. Epub 2011 
      Jul 2.