PMID- 2172541
OWN - NLM
STAT- MEDLINE
DCOM- 19901221
LR  - 20071114
IS  - 0047-2565 (Print)
IS  - 0047-2565 (Linking)
VI  - 19
IP  - 3-4
DP  - 1990
TI  - Evaluation of a HTLV-1 subunit vaccine in prevention of experimental STLV-I 
      infection in Macaca nemestrina.
PG  - 305-16
AB  - Pig-tailed macaques were vaccinated with a human T-cell lymphotropic virus type I 
      (HTLV-I) subunit vaccine. Vaccinates and controls were challenged with simian 
      T-cell lymphotropic virus type I (STLV-I)-infected cells. Vaccination yielded 
      antibody responses to HTLV-I and STLV-I gag and env precursors. Controls 
      developed HTLV-I and STLV-I antibody to gag and tax protein. Immunization 
      produced syncytium inhibiting antibody and cellular cytotoxicity to 
      virus-infected cells. Reverse transcriptase activity was present in control 
      macaques only, implying that the subunit vaccine was protective against STLV-I 
      infection.
FAU - Dezzutti, C S
AU  - Dezzutti CS
AD  - Department of Veterinary Pathobiology, Ohio State University, Columbus.
FAU - Frazier, D E
AU  - Frazier DE
FAU - Lafrado, L J
AU  - Lafrado LJ
FAU - Olsen, R G
AU  - Olsen RG
LA  - eng
GR  - NCI-CA40714/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Denmark
TA  - J Med Primatol
JT  - Journal of medical primatology
JID - 0320626
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Gene Products, env)
RN  - 0 (Gene Products, gag)
RN  - 0 (HTLV-I Antibodies)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/biosynthesis
MH  - Antibody-Dependent Cell Cytotoxicity
MH  - Antigens, Viral/immunology
MH  - Blotting, Western
MH  - Cell Line
MH  - Gene Products, env/immunology
MH  - Gene Products, gag/immunology
MH  - Giant Cells
MH  - HTLV-I Antibodies/biosynthesis
MH  - Human T-lymphotropic virus 1/*immunology
MH  - Macaca nemestrina
MH  - Retroviridae Infections/*prevention & control
MH  - Simian T-lymphotropic virus 1/*immunology
MH  - Vaccination
MH  - Viral Vaccines/*immunology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - J Med Primatol. 1990;19(3-4):305-16.