PMID- 21725939
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20171206
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 22
IP  - 2
DP  - 2012 Mar-Apr
TI  - 18FDG-PET/CT assessing the absence of cell viability and excluding metastatic 
      disease in a case of necrotic choroidal melanoma.
PG  - 288-92
LID - 10.5301/ejo.5000016 [doi]
AB  - PURPOSE: To report a case of choroidal melanoma in which the absence of 
      18FDG-positron emission tomography (PET)/computed tomography (CT) uptake in the 
      whole body scan excluded the presence of any foci of metastases. Additionally, 
      the PET/CT study correctly diagnosed the necrotic character of the lesion. 
      METHODS: A 76-year-old woman with neovascular glaucoma, and without vitreous or 
      retina visualization, was studied by our ophthalmology service. RESULTS: Ocular 
      ultrasound showed an 18 x 16 mm vitreous exophytic image compatible with 
      choroidal melanoma; magnetic resonance gave a 17 x 15 mm exophytic image, highly 
      intense at T1 and hypointense at T2, with cystic and necrotic images after a 
      contrast injection. An 18FDG-PET/CT study revealed a clearly hypometabolic 
      lesion, representing absence of cell viability and excluding active melanoma 
      cells. No other uptake lesions were detected at the whole-body PET/CT scan, 
      assuming the absence of extraocular metastases. The eye was enucleated, and the 
      pathology study showed a 16 x 15 mm necrotic choroidal melanoma. CONCLUSIONS: The 
      18FDG-PET/CT study correctly depicted the necrotic character of the choroidal 
      melanoma and was able to exclude other foci of metastases.
FAU - Romero-Aroca, Pedro
AU  - Romero-Aroca P
AD  - Ophthalmic Service, Institut de Investigacio Sanitaria Pere Virgili (IISPV), 
      Hospital Universitario Sant Joan, Universidad Rovira i Virgili, Reus, Spain. 
      promero@grupsagessa.com
FAU - Montero-Jaime, Manuel
AU  - Montero-Jaime M
FAU - Intriago, Belen
AU  - Intriago B
FAU - Riu, Frances
AU  - Riu F
FAU - Pena-Gonzalez, Karla B
AU  - Pena-Gonzalez KB
FAU - Almena-Garcia, Matias
AU  - Almena-Garcia M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Aged
MH  - Cell Survival
MH  - Choroid Neoplasms/*diagnostic imaging/pathology/surgery
MH  - Eye Enucleation
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Melanoma/*diagnostic imaging/pathology/surgery
MH  - *Multimodal Imaging
MH  - Necrosis
MH  - Orbit/diagnostic imaging
MH  - *Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - *Tomography, X-Ray Computed
MH  - Ultrasonography
EDAT- 2011/07/05 06:00
MHDA- 2012/08/30 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/05/21 00:00 [accepted]
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - 04DAF589-1EC8-4902-A0C7-9BEF52831552 [pii]
AID - 10.5301/ejo.5000016 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2012 Mar-Apr;22(2):288-92. doi: 10.5301/ejo.5000016.