PMID- 21726235
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20210102
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 66
IP  - 11
DP  - 2011 Nov
TI  - Primary brain tumours and specific serum immunoglobulin E: a case-control study 
      nested in the European Prospective Investigation into Cancer and Nutrition 
      cohort.
PG  - 1434-41
LID - 10.1111/j.1398-9995.2011.02670.x [doi]
AB  - BACKGROUND: Case-control studies suggest that patients with allergic diseases 
      have a lower risk of developing glioma but not meningioma or schwannoma. However, 
      those data can be differentially biased. Prospective studies with objective 
      measurements of immunologic biomarkers, like immunoglobulin E (IgE), in blood 
      obtained before cancer diagnosis could help to clarify whether an aetiological 
      association exists. METHODS: The present case-control study nested within the 
      European Prospective Investigation into Cancer and Nutrition (EPIC) measured 
      specific serum IgE as a biomarker for the most common inhalant allergens in 275 
      glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the 
      ImmunoCAP specific IgE test. Subjects with an IgE level >/=0.35 kUA/l (kilo 
      antibody units per litre) were classified as sensitized by allergens. Odds ratios 
      (OR) and 95% confidence intervals (CI) were estimated by adjusted conditional 
      logistic regression models for each tumour subtype. The effect of dose-response 
      relationship was assessed in five increasing IgE level categories to estimate 
      P-values for trend. RESULTS: The risk of glioma was inversely related to allergic 
      sensitization (OR = 0.73; 95% CI 0.51-1.06), especially pronounced in women (OR = 
      0.53; 95% CI 0.30-0.95). In dose-response analyses, for high-grade glioma, the 
      lowest OR was observed in sera with the highest IgE levels (P for trend = 0.04). 
      No association was seen for meningioma and schwannoma. CONCLUSION: The results, 
      based on serum samples prospectively collected in a cohort study, provide some 
      support for the hypothesis that individuals with allergic sensitization are at 
      reduced risk of glioma and confirm results from previous case-control studies.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Schlehofer, B
AU  - Schlehofer B
AD  - Unit of Environmental Epidemiology, German Cancer Research Centre, Heidelberg, 
      Germany. b.schlehofer@dkfz.de
FAU - Siegmund, B
AU  - Siegmund B
FAU - Linseisen, J
AU  - Linseisen J
FAU - Schuz, J
AU  - Schuz J
FAU - Rohrmann, S
AU  - Rohrmann S
FAU - Becker, S
AU  - Becker S
FAU - Michaud, D
AU  - Michaud D
FAU - Melin, B
AU  - Melin B
FAU - Bas Bueno-de-Mesquita, H
AU  - Bas Bueno-de-Mesquita H
FAU - Peeters, P H M
AU  - Peeters PH
FAU - Vineis, P
AU  - Vineis P
FAU - Tjonneland, A
AU  - Tjonneland A
FAU - Olsen, A
AU  - Olsen A
FAU - Overvad, K
AU  - Overvad K
FAU - Romieu, I
AU  - Romieu I
FAU - Boeing, H
AU  - Boeing H
FAU - Aleksandrova, K
AU  - Aleksandrova K
FAU - Trichopoulou, A
AU  - Trichopoulou A
FAU - Bamia, C
AU  - Bamia C
FAU - Lagiou, P
AU  - Lagiou P
FAU - Sacerdote, C
AU  - Sacerdote C
FAU - Palli, D
AU  - Palli D
FAU - Panico, S
AU  - Panico S
FAU - Sieri, S
AU  - Sieri S
FAU - Tumino, R
AU  - Tumino R
FAU - Sanchez, M-J
AU  - Sanchez MJ
FAU - Rodriguez, L
AU  - Rodriguez L
FAU - Dorronsoro, M
AU  - Dorronsoro M
FAU - Duell, E J
AU  - Duell EJ
FAU - Chirlaque, M-D
AU  - Chirlaque MD
FAU - Barricarte, A
AU  - Barricarte A
FAU - Borgquist, S
AU  - Borgquist S
FAU - Manjer, J
AU  - Manjer J
FAU - Gallo, V
AU  - Gallo V
FAU - Allen, N E
AU  - Allen NE
FAU - Key, T J
AU  - Key TJ
FAU - Riboli, E
AU  - Riboli E
FAU - Kaaks, R
AU  - Kaaks R
FAU - Wahrendorf, J
AU  - Wahrendorf J
LA  - eng
GR  - British Heart Foundation/United Kingdom
GR  - Medical Research Council/United Kingdom
GR  - Department of Health/United Kingdom
GR  - Cancer Research UK/United Kingdom
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110705
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allergens/immunology
MH  - Brain Neoplasms/diagnosis/*epidemiology/*immunology
MH  - Case-Control Studies
MH  - Europe/epidemiology
MH  - Female
MH  - Glioma/diagnosis/*epidemiology/*immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/diagnosis/*epidemiology/immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Meningioma/diagnosis/epidemiology/immunology
MH  - Middle Aged
MH  - Neurilemmoma/diagnosis/epidemiology/immunology
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2011/07/06 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - 10.1111/j.1398-9995.2011.02670.x [doi]
PST - ppublish
SO  - Allergy. 2011 Nov;66(11):1434-41. doi: 10.1111/j.1398-9995.2011.02670.x. Epub 
      2011 Jul 5.