PMID- 21728076
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20161020
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 22
IP  - 2
DP  - 2012 Apr
TI  - Frequency of fragmented QRS on ECG is increased in patients with rheumatoid 
      arthritis without cardiovascular disease: a pilot study.
PG  - 238-42
LID - 10.1007/s10165-011-0493-9 [doi]
AB  - Myocardial fibrosis causes the fragmentation of QRS complexes (fQRS) on ECGs. We 
      hypothesized that the frequency of fQRS could be more common in patients with 
      rheumatoid arthritis (RA) than in control subjects. A total of 56 patients with 
      RA were compared with 35 age- and gender-matched fibromyalgia subjects for fQRS. 
      The fQRS was defined as the presence of an additional R wave, or notching of the 
      R or S wave, or the presence of fragmentation in 2 contiguous leads corresponding 
      to the territory of a major coronary artery. Patients with bundle block on ECG 
      and cardiovascular disease were excluded. Twenty-one patients (37.5%) in the RA 
      group had fQRS, while two patients in the control group (5.7%) had fQRS (p = 
      0.001). No differences were found between the groups in terms of age, gender, or 
      drug use. Duration of disease--years (interquartile range [IQR])--was 10 (8) in 
      the fQRS (+) group, while it was 5 (2) in the fQRS (-) group (p < 0.001). 
      Multivariate logistic regression analysis revealed that duration of disease was 
      associated with the presence of fQRS (B = 1.5, odds ratio = 4.5, p = 0.004, 95% 
      confidence interval = 1.6-12.7). We found that fQRS on ECG was more common in 
      patients with RA without cardiovascular disease than in age- and gender-matched 
      control subjects.
FAU - Kadi, Hasan
AU  - Kadi H
AD  - Cardiology Department, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey. 
      drhkadi@gmail.com
FAU - Inanir, Ahmet
AU  - Inanir A
FAU - Habiboglu, Abdulkadir
AU  - Habiboglu A
FAU - Ceyhan, Koksal
AU  - Ceyhan K
FAU - Koc, Fatih
AU  - Koc F
FAU - Celik, Atac
AU  - Celik A
FAU - Onalan, Orhan
AU  - Onalan O
FAU - Arslan, Sule
AU  - Arslan S
LA  - eng
PT  - Journal Article
DEP - 20110705
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Adult
MH  - Antirheumatic Agents/therapeutic use
MH  - Arrhythmias, Cardiac/complications/diagnosis/*physiopathology
MH  - Arthritis, Rheumatoid/complications/diagnosis/*physiopathology
MH  - Electrocardiography/*methods
MH  - Female
MH  - Fibromyalgia/complications/diagnosis/physiopathology
MH  - Fibrosis/complications/pathology/physiopathology
MH  - Humans
MH  - Male
MH  - Myocardium/pathology
MH  - Pilot Projects
MH  - Prospective Studies
EDAT- 2011/07/06 06:00
MHDA- 2012/08/15 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/05/13 00:00 [received]
PHST- 2011/06/10 00:00 [accepted]
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.1007/s10165-011-0493-9 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2012 Apr;22(2):238-42. doi: 10.1007/s10165-011-0493-9. Epub 2011 
      Jul 5.