PMID- 21728395
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20170214
IS  - 1533-0338 (Electronic)
IS  - 1533-0338 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Aug
TI  - Expression of IGF-1R in colorectal polyps and its role in colorectal 
      carcinogenesis.
PG  - 381-9
AB  - Insulin-like Growth Factor Receptor 1 (IGF-1R) may play a role in the neoplastic 
      progression of colorectal cancer because it is related to both cellular 
      proliferation and differentiation. The aim of this study was to further elucidate 
      the role of IGF-1R in colorectal carcinogenesis by evaluating IGF-1R expression 
      in different types of precancerous colorectal polyps and comparing its expression 
      to normal mucosa and colorectal carcinoma. A total of 47 colorectal polyps and 
      their respective adjacent normal mucosa were collected from 32 patients. In 
      addition, 20 colorectal adenocarcinoma tissues were obtained from patients 
      undergoing colorectal resection, and 12 normal non-malignant colorectal mucosal 
      tissues collected from outpatients served as the control group. The pit patterns 
      of polyps were classified by the Kudo classification scheme through magnifying 
      chromoendoscopy. Immunohistochemistry and quantitative real-time RT-PCR were 
      utilized for expression analysis of IGF-1R in colorectal mucosa, polyps, and 
      adenocarcinoma tissue. The results of immunohistochemistry showed no significant 
      differences in IGF-1R expression in inflammatory polyps compared with their 
      surrounding normal mucosa by the Mann-Whitney U test (p=0.251); however, tubular 
      adenoma and villous adenoma tissues exhibited significantly higher levels of 
      IGF-1R expression (p=0.000). The results of real-time RT-PCR showed that IGF-1R 
      was transcribed at a high level in colorectal adenomatous polyps and 
      adenocarcinoma compared with their respective paired normal mucosa. Spearman's 
      rank correlation two-variable analysis was used to demonstrate a significant 
      correlation between the expression of IGF-1R and neoplastic progression from 
      normal mucosa to adenomatous polyps and finally to colorectal cancer (r=0.574, 
      p=0.000). This study suggests that the expression of IGF-1R correlates with the 
      degree of carcinogenesis. In addition, these results demonstrated that there is a 
      significant correlation between the level of IGF-1R expression and pit patterns 
      of polyps (r=0.432, p=0.002). Thus, IGF-1R might be a factor in the morphological 
      change of colorectal mucosal crypts, and it may play an important role in the 
      growth and malignant transformation of precancerous polyps. These results suggest 
      that IGF-1R can be considered a biomarker for the stage and risk of 
      carcinogenesis during neoplastic initiation and progression along the colorectal 
      normal mucosa-polyp-cancer sequence. Inhibitors of IGF-1R are not only a 
      promising targeted anticancer strategy, but also a possible option for the 
      chemoprevention of colorectal cancer.
FAU - Shan, H-B
AU  - Shan HB
AD  - State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, 
      P.R.China.
FAU - Zhang, R
AU  - Zhang R
FAU - Li, Y
AU  - Li Y
FAU - Xu, G-L
AU  - Xu GL
FAU - Luo, G-Y
AU  - Luo GY
FAU - Gao, X-Y
AU  - Gao XY
FAU - Yang, H-L
AU  - Yang HL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Adenocarcinoma/metabolism/*pathology
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*biosynthesis/genetics
MH  - Cell Transformation, Neoplastic/*metabolism/pathology
MH  - Colonic Polyps/metabolism/*pathology
MH  - Colorectal Neoplasms/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Receptor, IGF Type 1/*biosynthesis/genetics
MH  - Transcription, Genetic
EDAT- 2011/07/07 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - c4315/Expression-of-IGF-1R-in-Colorectal-Polyps-and-its-Role-in-Colorectal-Carcinogenesis-381-389-p17878.html 
      [pii]
AID - 10.7785/tcrt.2012.500215 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2011 Aug;10(4):381-9. doi: 10.7785/tcrt.2012.500215.