PMID- 21729750
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20191210
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Nov
TI  - Persistent organic pollutants have dose and CAG repeat length dependent effects 
      on androgen receptor activity in vitro.
PG  - 293-7
LID - 10.1016/j.reprotox.2011.06.075 [doi]
AB  - Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm 
      concentration was only seen in men with a short androgen receptor (AR) gene CAG 
      repeat. In order to investigate whether these effects could be observed also in 
      vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 
      1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5alpha-dihydrotestosterone 
      activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure 
      to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG 
      repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two 
      compounds was added. Thus, our in vitro results have confirmed the in vivo data 
      indicating a CAG repeat length dependent effect of endocrine disrupters on the AR 
      activity.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Bjork, Christel
AU  - Bjork C
AD  - Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund 
      University, Malmo, Sweden. christel.bjork@med.lu.se
FAU - Nenonen, Hannah
AU  - Nenonen H
FAU - Giwercman, Aleksander
AU  - Giwercman A
FAU - Bergman, Ake
AU  - Bergman A
FAU - Rylander, Lars
AU  - Rylander L
FAU - Giwercman, Yvonne Lundberg
AU  - Giwercman YL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110625
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Androgens)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Receptors, Androgen)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Androgens/pharmacology
MH  - Animals
MH  - COS Cells
MH  - Chlorocebus aethiops
MH  - Dichlorodiphenyl Dichloroethylene/*toxicity
MH  - Dihydrotestosterone/pharmacology
MH  - Environmental Pollutants/*toxicity
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Receptors, Androgen/*genetics/metabolism
MH  - *Trinucleotide Repeats
EDAT- 2011/07/07 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/03/02 00:00 [received]
PHST- 2011/05/09 00:00 [revised]
PHST- 2011/06/10 00:00 [accepted]
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0890-6238(11)00248-6 [pii]
AID - 10.1016/j.reprotox.2011.06.075 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2011 Nov;32(3):293-7. doi: 10.1016/j.reprotox.2011.06.075. Epub 
      2011 Jun 25.