PMID- 2173005
OWN - NLM
STAT- MEDLINE
DCOM- 19901213
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 48
IP  - 1
DP  - 1990 Jul
TI  - Intrahypothalamic implants of noradrenergic antagonists disrupt lordosis behavior 
      in female rats.
PG  - 31-6
AB  - There is considerable experimental evidence that hormonal activation of lordosis 
      in female rats involves norepinephrine (NE) neurotransmission. However, no clear 
      picture has emerged regarding either: 1) the neural sites at which NE influences 
      lordosis, or 2) the NE receptor subtype(s) mediating NE effects on lordosis. To 
      address these two issues, the behavioral effects of antagonists with relative 
      specificity for alpha 1, alpha 2, or beta adrenergic receptors were examined. 
      Drugs were administered via bilateral crystalline implants directly into the 
      ventromedial nucleus of the hypothalamus (VMN) or medial preoptic area (MPOA) of 
      ovariectomized female rats primed for 48 hr with 3 micrograms of estradiol 
      benzoate (EB) and given 200 micrograms of progesterone (P) 3.5-4 hr before 
      testing. When applied to the VMN 1 hr before the P injection, the alpha 1 
      receptor antagonist prazosin reduced lordosis behavior in 86% of animals but in 
      only 10% of rats when applied to the MPOA. However, prazosin did not inhibit 
      lordosis when implanted into the VMN just prior to EB administration. Yohimbine, 
      an alpha 2 receptor antagonist with low affinity for alpha 1 receptors, also 
      suppressed lordosis in 41% of animals with VMN implants and in 37% of rats with 
      MPOA implants. By contrast, the alpha 2 antagonist idazoxan, which has little 
      activity at alpha 1 receptors, did not significantly affect estrous responding 
      when implanted into either the VMN or MPOA. VMN implants of the beta receptor 
      antagonists propranolol and pindolol reduced lordosis behavior in 50% and 86% of 
      rats, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Etgen, A M
AU  - Etgen AM
AD  - Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461.
LA  - eng
GR  - MH00636/MH/NIMH NIH HHS/United States
GR  - MH41414/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Adrenergic)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Estrogens/physiology
MH  - Female
MH  - Norepinephrine/*physiology
MH  - Preoptic Area/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Adrenergic/*physiology
MH  - Sexual Behavior, Animal/*physiology
MH  - Synaptic Transmission/physiology
MH  - Ventromedial Hypothalamic Nucleus/*physiology
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
AID - 0031-9384(90)90256-4 [pii]
AID - 10.1016/0031-9384(90)90256-4 [doi]
PST - ppublish
SO  - Physiol Behav. 1990 Jul;48(1):31-6. doi: 10.1016/0031-9384(90)90256-4.