PMID- 21731388
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20231105
IS  - 0974-8490 (Electronic)
IS  - 0974-8490 (Linking)
VI  - 3
IP  - 1
DP  - 2011 Jan
TI  - Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) 
      whole fruit ethanolic extract in laboratory animals.
PG  - 2-8
LID - 10.4103/0974-8490.79108 [doi]
AB  - BACKGROUND: The present study was undertaken to evaluate the anti-ulcer and 
      antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB) 
      whole fruit in laboratory rats. METHODS: The anti-ulcer property of the ethanolic 
      extract of the whole fruit of Lagenaria breviflora (LB) was assessed using the 
      cold-restraint stress-induced (CRU) gastric ulcer, pyloric ligation-induced (PL) 
      gastric ulcer, aspirin-induced (ASP) gastric ulcer and alcohol-induced (AL) 
      gastric ulcer models. The scavenging activity of the LB extract was examined with 
      1, 1-diphenyl-2-picryl-hydrazyl (DPPH), Nitric oxide, Hydroxyl radical and 
      Superoxide anion scavenging models. RESULTS: EELB (50, 100, 150 and 200 mg/kg, 
      b.w.) protected against the CRU gastric ulcer dose dependently. Similarly, 150 
      mg/kg b.w. of the LB extract protected against the PL gastric ulcer, ASP gastric 
      ulcer and AL gastric ulcer and was comparable to omeprazole (10 mg/kg b.w.) or 
      Suscralfate (500 mg/kg b.w.), respectively. The in vitro antioxidant activity of 
      LB was demonstrated by its ability to quench free radicals generated by nitric 
      oxide and superoxide anion with a concomitant scavenging potential against 
      DPPH-induced radical formation. CONCLUSION: Taken together, the study showed that 
      the whole fruit extract possess potent anti-ulcer and antioxidant activities.
FAU - Onasanwo, S A
AU  - Onasanwo SA
AD  - Department of Physiology, College of Medicine, University of Ibadan, Ibadan, 
      Nigeria.
FAU - Singh, Neetu
AU  - Singh N
FAU - Saba, A B
AU  - Saba AB
FAU - Oyagbemi, A A
AU  - Oyagbemi AA
FAU - Oridupa, O A
AU  - Oridupa OA
FAU - Palit, Gautam
AU  - Palit G
LA  - eng
PT  - Journal Article
PL  - India
TA  - Pharmacognosy Res
JT  - Pharmacognosy research
JID - 101558769
PMC - PMC3119267
OTO - NOTNLM
OT  - Anti-ulcer
OT  - antioxidant
OT  - free radical scavenger
EDAT- 2011/07/07 06:00
MHDA- 2011/07/07 06:01
CRDT- 2011/07/07 06:00
PHST- 2010/09/14 00:00 [received]
PHST- 2010/11/07 00:00 [revised]
PHST- 2011/04/07 00:00 [accepted]
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/07/07 06:01 [medline]
AID - PR-3-2 [pii]
AID - 10.4103/0974-8490.79108 [doi]
PST - ppublish
SO  - Pharmacognosy Res. 2011 Jan;3(1):2-8. doi: 10.4103/0974-8490.79108.