PMID- 21732770
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20220310
IS  - 1543-2165 (Electronic)
IS  - 0003-9985 (Linking)
VI  - 135
IP  - 7
DP  - 2011 Jul
TI  - Update on fluorescence in situ hybridization in melanoma: state of the art.
PG  - 830-7
AB  - CONTEXT: Recent advances in understanding the molecular basis of melanoma have 
      resulted in development of fluorescence in situ hybridization (FISH) protocols 
      designed to detect genetic abnormalities discriminating melanoma from nevi. The 
      most extensively studied is a 4-probe multicolor FISH probe panel targeting 
      chromosomes 6 and 11. Validation studies showed promising sensitivity and 
      specificity for distinguishing benign nevi and malignant melanoma by FISH. Recent 
      studies show that a melanoma FISH assay has great potential for becoming an 
      important diagnostic adjunct in classification of melanocytic lesions and in 
      diagnosis of melanoma. OBJECTIVE: To present a comprehensive review of the 
      science and practical aspects of FISH in melanoma for pathologists considering 
      the use of melanoma FISH in their practice. DATA SOURCES: Review of the 
      literature and personal experience of the authors. CONCLUSIONS: Judicious use of 
      a 4-probe multicolor melanoma FISH procedure can enhance accuracy for diagnosis 
      of melanoma and improve classification of melanocytic proliferations.
FAU - Gerami, Pedram
AU  - Gerami P
AD  - Department of Dermatology, Northwestern University and the Feinberg School of 
      Medicine, Chicago, Illinois, USA.
FAU - Zembowicz, Artur
AU  - Zembowicz A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
SB  - IM
EIN - Arch Pathol Lab Med. 2011 Oct;135(10):1237
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Melanoma/*diagnosis/genetics
MH  - Nevus, Pigmented/diagnosis/genetics
MH  - Skin Neoplasms/*diagnosis/genetics
EDAT- 2011/07/08 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 10.1043/2011-0048-RAIR.1 [pii]
AID - 10.5858/2011-0048-RAIR.1 [doi]
PST - ppublish
SO  - Arch Pathol Lab Med. 2011 Jul;135(7):830-7. doi: 10.5858/2011-0048-RAIR.1.