PMID- 21732793
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20211020
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 27
IP  - 12
DP  - 2011 Dec
TI  - Molecular characteristics of HIV type 1 infection among prisoners from Central 
      Western Brazil.
PG  - 1349-53
LID - 10.1089/aid.2011.0153 [doi]
AB  - Abstract This study among antiretroviral-experienced prisoners from central 
      western Brazil investigated mutations associated with secondary resistance to 
      nucleoside/nonnucleoside reverse transcriptase inhibitors (NRTI/NNRTI), protease 
      inhibitors (Stanford HIV-1 Resistance/International Aids Society Databases), and 
      HIV-1 subtypes (REGA/phylogenetic analyses/SimPlot). Twenty-seven prisoners from 
      three prisons (16 males and four females from Mato Grosso do Sul State and seven 
      males from Goias State) had HIV-1 protease and reverse transcriptase fragments 
      sequenced after nested PCR. Median age was 35 years. Seven males and two females 
      were intravenous drug users, three males referred homosexual practice. Resistance 
      mutations were present in 37% (10/27): NRTI+NNRTI mutations (n=5), NRTI mutations 
      (n=3), multidrug-resistant mutations (n=2). Subtype B (48%), subtype C (11%), 
      B/F1, B/C, and F1/B/C recombinants (40.7%) were detected. Possible intraprison 
      transmissions were identified: two intravenous drug user females (subtype C); two 
      clusters among homosexual males (subtype B and B/F1). High resistance rate and 
      possible intraprison transmission highlight the need for improved prevention, 
      counseling, and treatment strategies for prisoners.
FAU - Cardoso, Ludimila Paula Vaz
AU  - Cardoso LP
AD  - Tropical Pathology and Public Health Institute, Federal University of Goias, 
      Brazil.
FAU - da Silveira, Alexsander Augusto
AU  - da Silveira AA
FAU - Francisco, Roberta Barbosa Lopes
AU  - Francisco RB
FAU - da Guarda Reis, Monica Nogueira
AU  - da Guarda Reis MN
FAU - Stefani, Mariane Martins de Araujo
AU  - Stefani MM
LA  - eng
SI  - GENBANK/HQ831450
SI  - GENBANK/HQ831476
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110706
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*virology
MH  - Adult
MH  - Base Sequence
MH  - Brazil
MH  - Drug Resistance, Multiple, Viral/genetics
MH  - Female
MH  - HIV Infections/*virology
MH  - HIV-1/classification/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - *Prisoners
PMC - PMC3227242
EDAT- 2011/07/08 06:00
MHDA- 2012/02/24 06:00
PMCR- 2012/12/01
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - 10.1089/aid.2011.0153 [pii]
AID - 10.1089/aid.2011.0153 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2011 Dec;27(12):1349-53. doi: 10.1089/aid.2011.0153. 
      Epub 2011 Jul 6.