PMID- 21732917 OWN - NLM STAT- MEDLINE DCOM- 20120112 LR - 20110920 IS - 1399-0039 (Electronic) IS - 0001-2815 (Linking) VI - 78 IP - 4 DP - 2011 Oct TI - Characterization of 236 novel alleles at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci from China Marrow Donor Program. PG - 267-70 LID - 10.1111/j.1399-0039.2011.01731.x [doi] AB - Two hundred and thirty-six novel human leukocyte antigen (HLA) alleles are described from volunteer donors of the China Marrow Donor Program: 71 HLA-A alleles, 79 HLA-B alleles, 43 HLA-C, 16 HLA-DRB1 alleles, 26 HLA-DQB1 and 1 HLA-DPB1. Two hundred and thirteen (90.3%) of the 236 novel alleles are single nucleotide substitution variants when compared with their most homologous allele. Seventy-eight of these single nucleotide variants are silent substitutions. The remaining novel alleles differ from their most similar allele by two to four nucleotide substitutions. Some of the novel alleles encode amino acid changes at positions not previously reported to be polymorphic, such as codons 57, 62, 67, 41 and 52 in HLA-A alleles; codons 133, 156, 201 and 215 in HLA-B alleles; codons 74, 208 and 225 in HLA-C; codons 25, 32 and 72 in HLA-DRB1; codons 20, 39 and 77 in HLA-DQB1. CI - (c) 2011 John Wiley & Sons A/S. FAU - Li, J AU - Li J AD - Beijing Genomics Institute at Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen, China. lijian@genomics.org.cn FAU - Qu, J AU - Qu J FAU - Zhang, X AU - Zhang X FAU - Zhang, C AU - Zhang C FAU - Liu, Y AU - Liu Y FAU - Cao, H AU - Cao H FAU - Zhang, W AU - Zhang W FAU - Wang, Y AU - Wang Y FAU - Chen, H AU - Chen H FAU - Chen, G AU - Chen G FAU - Zheng, Z AU - Zheng Z FAU - Shen, M AU - Shen M FAU - Cheng, Z AU - Cheng Z FAU - Tang, J AU - Tang J FAU - Zhen, H AU - Zhen H FAU - Liao, K AU - Liao K FAU - Chen, C AU - Chen C FAU - Yang, H AU - Yang H FAU - Tian, Z AU - Tian Z FAU - Zhang, H AU - Zhang H FAU - Hua, S AU - Hua S FAU - Rao, B AU - Rao B FAU - Wang, N AU - Wang N FAU - Zhang, Q AU - Zhang Q FAU - Liu, T AU - Liu T FAU - Chen, S AU - Chen S FAU - Wang, L AU - Wang L FAU - Yi, X AU - Yi X LA - eng PT - Journal Article DEP - 20110707 PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (Codon) RN - 0 (HLA-A Antigens) RN - 0 (HLA-B Antigens) RN - 0 (HLA-C Antigens) RN - 0 (HLA-DP beta-Chains) RN - 0 (HLA-DPB1 antigen) RN - 0 (HLA-DQ beta-Chains) RN - 0 (HLA-DQB1 antigen) RN - 0 (HLA-DRB1 Chains) SB - IM MH - *Alleles MH - Amino Acid Substitution MH - China MH - Codon/genetics MH - Female MH - Genetic Loci/*physiology MH - HLA-A Antigens/*genetics MH - HLA-B Antigens/*genetics MH - HLA-C Antigens/*genetics MH - HLA-DP beta-Chains/*genetics MH - HLA-DQ beta-Chains/*genetics MH - HLA-DRB1 Chains/*genetics MH - Humans MH - Male MH - National Health Programs MH - Polymorphism, Genetic MH - *Tissue Donors EDAT- 2011/07/08 06:00 MHDA- 2012/01/13 06:00 CRDT- 2011/07/08 06:00 PHST- 2011/07/08 06:00 [entrez] PHST- 2011/07/08 06:00 [pubmed] PHST- 2012/01/13 06:00 [medline] AID - 10.1111/j.1399-0039.2011.01731.x [doi] PST - ppublish SO - Tissue Antigens. 2011 Oct;78(4):267-70. doi: 10.1111/j.1399-0039.2011.01731.x. Epub 2011 Jul 7.