PMID- 21736409
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20171116
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 24
IP  - 10
DP  - 2011 Oct
TI  - Influence of coconut oil administration on some hematologic and metabolic 
      parameters in pregnant rats.
PG  - 1254-8
LID - 10.3109/14767058.2011.572308 [doi]
AB  - OBJECTIVE: Data on the effect of coconut oil intake on various hematologic and 
      metabolic parameters in pregnant women or animals are scanty. Hence we attempted 
      to assess the effect of oral administration of graded doses of this edible oil 
      during pregnancy, on various hematologic and metabolic parameters in rats. 
      METHODS: Groups of pregnant Sprague Dawley rats were given oral doses of 1 ml, 2 
      ml, and 4 ml coconut oil twice per day, respectively. Control group of rats were 
      given tap water. Oral feeding of oil was done continuously for a period of 20 
      days and at the end of the study period the animals were lightly anaesthetized 
      with ether and sacrificed to collect blood samples for analysis. Various 
      hematologic parameters such as red blood cell (RBC) count, white blood cell (WBC) 
      count, hemoglobin (Hg), platelets, lymphocytes, and mean corpuscular hemoglobin 
      concentration (MCHC) were analyzed by a hematology blood analyzer, while 
      metabolic parameters such as cholesterol, triglycerides, urea, uric acid, 
      creatinine, and protein were analyzed by specific analytical kits. Activities of 
      antioxidant enzyme, superoxide dismutase (SOD), glutathione peroxidase (GPX), and 
      total antioxidant activity (TAO) were assessed by specific analytical kits. 
      Statistical analysis of data was performed using a SPSS data analytical package. 
      RESULTS: Oral administration of coconut oil for 20 continuous days of pregnancy 
      did not significantly alter any of the hematologic parameters studied, compared 
      to control group even when the oil was administered at a relatively massive dose 
      of 4 ml/day. Administration of coconut oil appeared to decrease WBC, Hg, 
      platelet, and lymphocyte blood concentrations in treated rats, but the 
      difference, however, was not statistically significant (ANOVA test; p > 0.05). 
      However, platelet concentration was significantly lower (p < 0.05) in rats 
      receiving 1 ml/day of coconut oil compared to control group rats. Administration 
      of coconut oil did not alter the concentrations of protein, cholesterol, urea, 
      triglycerides, uric acid, and creatinine in treated groups of rats significantly 
      (Student's t-test, p > 0.05) compared to those of control rats. SOD, GPX, and TAO 
      levels in control and treated groups were not significantly different (ANOVA 
      test, p > 0.05) than controls. CONCLUSIONS: We conclude that oral administration 
      of coconut oil during pregnancy in rats, even in massive doses, does not cause 
      any significant alterations in hematologic and metabolic parameters. More 
      detailed studies, however, are warranted before extrapolating these results to 
      human situations.
FAU - Nandakumaran, Moorkath
AU  - Nandakumaran M
AD  - Departments of Obstetrics and Gynecology, Faculty of Medicine, University of 
      Kuwait, Kuwait City, Kuwait. moorkath@hsc.edu.kw
FAU - Angelaki, Elisaveth
AU  - Angelaki E
FAU - Al-Azemi, Nasser
AU  - Al-Azemi N
FAU - Al-Sarraf, Hameed
AU  - Al-Sarraf H
FAU - Al-Saleh, Eyad
AU  - Al-Saleh E
LA  - eng
PT  - Journal Article
DEP - 20110707
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Blood Proteins)
RN  - 0 (Hemoglobins)
RN  - 0 (Plant Oils)
RN  - 0 (Triglycerides)
RN  - 268B43MJ25 (Uric Acid)
RN  - 8W8T17847W (Urea)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - Q9L0O73W7L (Coconut Oil)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - *Blood Cell Count
MH  - Blood Proteins/drug effects
MH  - Cholesterol/blood
MH  - Coconut Oil
MH  - Female
MH  - Hemoglobins/metabolism
MH  - Plant Oils/*administration & dosage/metabolism
MH  - Pregnancy/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Triglycerides/blood
MH  - Urea/blood
MH  - Uric Acid/blood
EDAT- 2011/07/09 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10.3109/14767058.2011.572308 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2011 Oct;24(10):1254-8. doi: 
      10.3109/14767058.2011.572308. Epub 2011 Jul 7.