PMID- 21736779
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20211020
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Print)
IS  - 0007-1145 (Linking)
VI  - 106
IP  - 12
DP  - 2011 Dec
TI  - Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 
      concentration in mice fed a diet containing a high level of saturated fat.
PG  - 1810-3
LID - 10.1017/S0007114511002157 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine 
      up-regulated in obese subjects, contributing to the development of type 2 
      diabetes. The present study investigated the inhibitory effect of an 
      ethanol-water extract from bamboo (BEX, Phyllostachys edulis) on the blood 
      concentration of MCP-1. C57BL/6J mice were fed a standard diet or a high-fat diet 
      with or without the BEX supplement (11 g dry mass/17 000 kJ) for 6 months. A 
      total of ten mice were used in each group. Body weight and food consumption were 
      measured weekly. After euthanisation, the weight of visceral fat and circulating 
      MCP-1 concentration were measured. In comparison with the standard control group, 
      the high-fat control group had increased body weight, abdominal fat storage and 
      serum MCP-1 concentration by 60 % (P < 0.001), 266 % (P < 0.001) and 180 % 
      (P < 0.01), respectively. In comparison with the high-fat control group, the 
      high-fat BEX group showed a 3 % decrease in body weight (P < 0.01), 24 % decrease 
      in mesenteric fat depot (P < 0.01) and 49 % decrease in serum MCP-1 concentration 
      (P < 0.05). The present study suggests that the BEX supplement in the high-fat 
      diet ameliorates elevated MCP-1 concentrations in the blood, and whether this is 
      related to modulated endocrine properties of the visceral fat is to be studied.
FAU - Higa, Jason K
AU  - Higa JK
AD  - Department of Cell and Molecular Biology, John A. Burns School of Medicine, 
      University of Hawaii at Manoa, 651 Ilalo Street BSB 222, Honolulu, HI 96813, USA.
FAU - Liu, Wanyu
AU  - Liu W
FAU - Berry, Marla J
AU  - Berry MJ
FAU - Panee, Jun
AU  - Panee J
LA  - eng
GR  - R21 AT005139-01/AT/NCCIH NIH HHS/United States
GR  - R21 AT003874/AT/NCCIH NIH HHS/United States
GR  - R21 AT003874-02/AT/NCCIH NIH HHS/United States
GR  - U54 MD007584/MD/NIMHD NIH HHS/United States
GR  - R21 AT005139/AT/NCCIH NIH HHS/United States
GR  - 5G12RR003061-23/RR/NCRR NIH HHS/United States
GR  - 5P20 MD000173-08/MD/NIMHD NIH HHS/United States
GR  - G12 RR003061/RR/NCRR NIH HHS/United States
GR  - P20 MD000173/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*blood
MH  - Diet, High-Fat/*adverse effects
MH  - *Dietary Supplements
MH  - Intra-Abdominal Fat/anatomy & histology/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Organ Size/drug effects
MH  - Plant Extracts/*administration & dosage
MH  - Poaceae/*chemistry
PMC - PMC4659480
MID - NIHMS739227
COIS- Conflicts of interest: The authors declare that there are no conflicts of 
      interest.
EDAT- 2011/07/09 06:00
MHDA- 2012/01/21 06:00
PMCR- 2015/11/25
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
PHST- 2015/11/25 00:00 [pmc-release]
AID - S0007114511002157 [pii]
AID - 10.1017/S0007114511002157 [doi]
PST - ppublish
SO  - Br J Nutr. 2011 Dec;106(12):1810-3. doi: 10.1017/S0007114511002157. Epub 2011 Jun 
      7.