PMID- 21736787
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20131121
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 106
IP  - 10
DP  - 2011 Nov
TI  - A dairy product fermented by lactobacilli cancels the adverse effects of 
      hypochlorhydria induced by a proton pump inhibitor on bone metabolism in growing 
      rats.
PG  - 1487-94
LID - 10.1017/S0007114511002017 [doi]
AB  - The purpose of the present study is to investigate the effects of hypochlorhydria 
      induced by proton pump inhibitor (PPI) administration and intake of a dairy 
      product fermented by lactobacilli (DFL) on bone metabolism in growing rats. Male 
      rats, aged 3 weeks, were divided into two groups: a control group fed a 
      casein-based diet and a group fed a DFL-based diet. Each group was fed its 
      respective experimental diets for 9 d. At day 5 of the feeding period, each group 
      was divided into two subgroups: one that received a saline injection and one that 
      received a PPI injection. Rats were subcutaneously administered saline or PPI for 
      5 d. Faecal Ca excretion was determined from day 6 to day 9. At the end of the 
      experiment, plasma and femurs were collected. Administration of PPI significantly 
      decreased bone mineral density (shown by X-ray computerised tomography) and bone 
      strength (shown by a three-point bending test) in the control group. Plasma 
      osteocalcin, type I collagen C-telopeptides, 1,25-dihydroxyvitamin D and 
      parathyroid hormone concentrations were elevated by PPI administration in the 
      control group. Faecal Ca excretion and urinary P excretion in the control group 
      were remarkably increased by PPI administration. On the other hand, these adverse 
      effects of PPI were not observed in the DFL group. These results suggest that 
      hypochlorhydria-induced bone loss may result from high bone turnover induced by 
      secondary hyperparathyroidism due to Ca malabsorption and that DFL intake cancels 
      these adverse effects probably via improving Ca malabsorption in growing rats.
FAU - Takasugi, Satoshi
AU  - Takasugi S
AD  - Food Science Institute, Division of Research and Development, Meiji Dairies 
      Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan. 
      satoshi.takasugi@meiji-milk.com
FAU - Ashida, Kinya
AU  - Ashida K
FAU - Maruyama, Suyaka
AU  - Maruyama S
FAU - Komaba, Yukari
AU  - Komaba Y
FAU - Kaneko, Tetsuo
AU  - Kaneko T
FAU - Yamaji, Taketo
AU  - Yamaji T
LA  - eng
PT  - Journal Article
DEP - 20110607
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Proton Pump Inhibitors)
RN  - 27YLU75U4W (Phosphorus)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Achlorhydria/*metabolism
MH  - Animals
MH  - Body Weight
MH  - Bone Density
MH  - Bone and Bones/drug effects/*metabolism
MH  - Calcium/metabolism
MH  - *Dairy Products
MH  - *Fermentation
MH  - Gastric Juice/metabolism
MH  - Hydrogen-Ion Concentration
MH  - Lactobacillus/*metabolism
MH  - Male
MH  - Phosphorus/metabolism
MH  - Proton Pump Inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tomography, X-Ray Computed
EDAT- 2011/07/09 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - S0007114511002017 [pii]
AID - 10.1017/S0007114511002017 [doi]
PST - ppublish
SO  - Br J Nutr. 2011 Nov;106(10):1487-94. doi: 10.1017/S0007114511002017. Epub 2011 
      Jun 7.