PMID- 21737555
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20220317
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 39
IP  - 3
DP  - 2012 Mar
TI  - Genetic variants associated with severe pneumonia in A/H1N1 influenza infection.
PG  - 604-10
LID - 10.1183/09031936.00020611 [doi]
AB  - The A/H1N1 influenza strain isolated in Mexico in 2009 caused severe pulmonary 
      illness in a small number of exposed individuals. Our objective was to determine 
      the influence of genetic factors on their susceptibility. We carried out a 
      case-control association study genotyping 91 patients with confirmed severe 
      pneumonia from A/H1N1 infection and 98 exposed but asymptomatic household 
      contacts, using the HumanCVD BeadChip (Illumina, San Diego, CA, USA). Four risk 
      single-nucleotide polymorphisms were significantly (p<0.0001) associated with 
      severe pneumonia: rs1801274 (Fc fragment of immunoglobulin G, low-affinity IIA, 
      receptor (FCGR2A) gene, chromosome 1; OR 2.68, 95% CI 1.69-4.25); rs9856661 (gene 
      unknown, chromosome 3; OR 2.62, 95% CI 1.64-4.18); rs8070740 (RPA interacting 
      protein (RPAIN) gene, chromosome 17; OR 2.67, 95% CI 1.63-4.39); and rs3786054 
      (complement component 1, q subcomponent binding protein (C1QBP) gene, chromosome 
      17; OR 3.13, 95% CI 1.89-5.17). All SNP associations remained significant after 
      adjustment for sex and comorbidities. The SNPs on chromosome 17 were in linkage 
      disequilibrium. These findings revealed that gene polymorphisms located in 
      chromosomes 1 and 17 might influence susceptibility to development of severe 
      pneumonia in A/H1N1 infection. Two of these SNPs are mapped within genes (FCGR2A, 
      C1QBP) involved in the handling of immune complexes and complement activation, 
      respectively, suggesting that these genes may confer risk due to increased 
      activation of host immunity.
FAU - Zuniga, J
AU  - Zuniga J
AD  - Instituto Nacional deEnfermedades Respiratorias IsmaelCosio Villegas, Universidad 
      Nacional Autonoma de Mexico, Mexico City, Mexico.
FAU - Buendia-Roldan, I
AU  - Buendia-Roldan I
FAU - Zhao, Y
AU  - Zhao Y
FAU - Jimenez, L
AU  - Jimenez L
FAU - Torres, D
AU  - Torres D
FAU - Romo, J
AU  - Romo J
FAU - Ramirez, G
AU  - Ramirez G
FAU - Cruz, A
AU  - Cruz A
FAU - Vargas-Alarcon, G
AU  - Vargas-Alarcon G
FAU - Sheu, C-C
AU  - Sheu CC
FAU - Chen, F
AU  - Chen F
FAU - Su, L
AU  - Su L
FAU - Tager, A M
AU  - Tager AM
FAU - Pardo, A
AU  - Pardo A
FAU - Selman, M
AU  - Selman M
FAU - Christiani, D C
AU  - Christiani DC
LA  - eng
GR  - HL060710/HL/NHLBI NIH HHS/United States
GR  - ES00002/ES/NIEHS NIH HHS/United States
GR  - R01 HL060710/HL/NHLBI NIH HHS/United States
GR  - HL095732/HL/NHLBI NIH HHS/United States
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - R01 HL095732/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110707
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (C1QBP protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (FCGR2A protein, human)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Adult
MH  - Carrier Proteins/genetics
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 17
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*genetics/immunology
MH  - Linkage Disequilibrium
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Mitochondrial Proteins/genetics
MH  - Pneumonia, Viral/*genetics/immunology
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, IgG/genetics
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC3816497
MID - NIHMS524177
COIS- STATEMENT OF INTEREST None declared.
EDAT- 2011/07/09 06:00
MHDA- 2012/07/17 06:00
PMCR- 2013/11/04
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
PHST- 2013/11/04 00:00 [pmc-release]
AID - 09031936.00020611 [pii]
AID - 10.1183/09031936.00020611 [doi]
PST - ppublish
SO  - Eur Respir J. 2012 Mar;39(3):604-10. doi: 10.1183/09031936.00020611. Epub 2011 
      Jul 7.