PMID- 2173796
OWN - NLM
STAT- MEDLINE
DCOM- 19901231
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 64
IP  - 12
DP  - 1990 Dec
TI  - Putative site for the acquisition of human herpesvirus 6 virion tegument.
PG  - 6308-13
AB  - The virion of human herpesvirus 6 (HHV-6) contains a very distinct tegument 
      layer, occupying the space between the nucleocapsid and the virion envelope. 
      Ultrastructural analyses of thymocytes infected with HHV-6 revealed the presence 
      of intranuclear spherical compartments, approximately 1.5 microns in diameter, in 
      which tegumentation seems to take place. These compartments, termed tegusomes, 
      were bounded by two membranes and contained ribosomes, consistent with their 
      derivation by cytoplasmic invagination into the nucleus. Capsids located within 
      the nucleus outside the tegusomes were all naked, while those located in the 
      cytoplasm were uniformly tegumented. In contrast, capsids present inside the 
      tegusomes contains teguments of variable thicknesses. In addition, nucleocapsids 
      were documented in the process of budding into the tegusomes. We thus suggest 
      that the tegusomes represent a cellular site in which HHV-6 virions acquire their 
      tegument.
FAU - Roffman, E
AU  - Roffman E
AD  - Laboratory of Viral Diseases, National Institute of Allergy and Infectious 
      Diseases/Twinbrook, Rockville, Maryland.
FAU - Albert, J P
AU  - Albert JP
FAU - Goff, J P
AU  - Goff JP
FAU - Frenkel, N
AU  - Frenkel N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
SB  - IM
MH  - Cell Nucleus/ultrastructure
MH  - Cell Transformation, Viral
MH  - Cells, Cultured
MH  - Herpesvirus 6, Human/genetics/*physiology/ultrastructure
MH  - Humans
MH  - Microscopy, Electron
MH  - T-Lymphocytes/ultrastructure
MH  - Virion/genetics/*physiology/ultrastructure
MH  - *Virus Replication
PMC - PMC248811
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
PMCR- 1990/12/01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
PHST- 1990/12/01 00:00 [pmc-release]
AID - 10.1128/JVI.64.12.6308-6313.1990 [doi]
PST - ppublish
SO  - J Virol. 1990 Dec;64(12):6308-13. doi: 10.1128/JVI.64.12.6308-6313.1990.