PMID- 2173798
OWN - NLM
STAT- MEDLINE
DCOM- 19901231
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 64
IP  - 12
DP  - 1990 Dec
TI  - naf, a trans-regulating negative-acting factor encoded within the mouse mammary 
      tumor virus open reading frame region.
PG  - 6355-9
AB  - The mouse mammary tumor virus (MMTV) long terminal repeat (LTR) open reading 
      frame (ORF) encodes a negative acting factor (naf). In our test system, naf 
      mediates its effect in trans on another MMTV provirus in which the 5' LTR has 
      been replaced by that of Rous sarcoma virus. naf effects are evidenced at the 
      level of transcriptional initiation rather than as reduced mRNA stability. The 
      introduction of a premature termination codon into the MMTV LTR-encoded ORF 
      abolishes the transcriptional down regulation localizing naf within the ORF. In 
      addition, sequences in the gag/pol genes between +320 and +646 and between +3626 
      and +4590 relative to the site of transcription initiation are also involved in 
      the MMTV-mediated transcriptional down regulation.
FAU - Salmons, B
AU  - Salmons B
AD  - GSF-Munchen, Abteilung fur Molekulare Zellpathologie, Neuherberg, Federal 
      Republic of Germany.
FAU - Erfle, V
AU  - Erfle V
FAU - Brem, G
AU  - Brem G
FAU - Gunzburg, W H
AU  - Gunzburg WH
LA  - eng
GR  - CA45123-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (RNA, Messenger)
SB  - IM
GS  - naf
MH  - Amino Acid Sequence
MH  - Animals
MH  - Avian Sarcoma Viruses/genetics
MH  - Base Sequence
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Gene Expression Regulation, Viral
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Molecular Sequence Data
MH  - *Open Reading Frames
MH  - Proviruses/genetics
MH  - RNA, Messenger/genetics
MH  - Repetitive Sequences, Nucleic Acid
MH  - Transcription, Genetic
MH  - *Transcriptional Activation
MH  - Transfection
PMC - PMC248820
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
PMCR- 1990/12/01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
PHST- 1990/12/01 00:00 [pmc-release]
AID - 10.1128/JVI.64.12.6355-6359.1990 [doi]
PST - ppublish
SO  - J Virol. 1990 Dec;64(12):6355-9. doi: 10.1128/JVI.64.12.6355-6359.1990.